ATSEKLIDIN (Aceclidinum). 3-Atsetoksihinuklidina musk.

     Synonyms : Aceclidine, Glaucstat (hydrochloride), Glaudin, Glaunorm.

     The white crystalline powder. The easily soluble in water. Aqueous solutions (pH 4, 5, 5, 5) in sterile +100' C for the PC min.

     Is holinomimeticheskim substances, enabling predominantly holinoreaktivnye system.

     On Aceclidine chemical structure of the derivatives 3-oksihinuklidina (see also Oksilidin, Imehin, Temehin).

     He kinship with the molecule acetylcholine and creates conditions for bonding with atseklidina holinoretseptorami.

     Unlike Aceclidine acetylcholine is not forbidden, and the tertiary base, which allows entry atseklidina gistogematicheskie through barriers, including through the blood-brain barrier.

     With the organism Aceclidine enhance the functions of the relevant holinergicheskuyu innervation. Especially expressed preparation to increase capacity and enhance inflammatory bowel reduction, bladder, uterus. At higher doses may occur aetiology, lowering blood pressure, increased salivatsii, bronhiolospazm. The drug has a great effect mioticheskoe; Maybe by narrowing down inner pressure. Step atseklidina removed and cautions when applying atropine and other holinoliticheskih substances.

     The drug is readily absorbed in a different way, including backfilling in konyunktivalny bag.

     Aceclidine applied mainly as a means of warning and eliminates atony bladder, especially in increasing the number of urine associated with neyrogennymi disorders bladder muscles atony in the gastrointestinal tract, as well as obstetric practice at the low tone and subinvolyutsii uterus, to stop bleeding in the postpartum period.

     In practice, ophthalmic solutions used to narrow atseklidina missed and lower inner pressure in glaucoma.

     In atony stomach, intestines and bladder and uterus hypotonia enter into the skin to 1 to 2 ml of 0.2% solution atseklidina. With insufficient effects injections repeat 2 - 3 times at intervals of 20 minutes 30. If there is evidence (if subinvolyutsii uterus etc.) Injection atseklidina to within 2 to 3 days.

     Aceclidine - pharmacological valuable tool for x-rays oesophagus, stomach and duodenal ulcers. To identify ahalazii oesophagus caused by the parasympathetic Wilhelm, entering into the skin 0.75 to 1 ml 0.2% atseklidina solution for 15 min before the patient barievoy mist. To clarify the nature of the defeat of stomach and duodenal ulcers are (after conventional x-ray) under the skin 0,5-1 ml 0.2% atseklidina solution, and after 12 to 15 minutes after giving an additional portion barievoy mist to re-study.

     Aceclidine not inferior to the efficiency of morphine, no side effects.

     In ophthalmic practice Aceclidine appointed as eye drops (2%, 3% and 5% aqueous solutions). Started with backfilling 2% solution. In this usually has a small miotichesky and anti-hypertensive effect; For greater use of 3% and 5% solutions. Frequency backfilling (3 to 6 times a day) depends on the earnings impact. Usually after a single backfilling mioticheskoe and anti-hypertensive effect until 6 h or more.

     Aceclidine can be used in combination with other miotikami. 5% solution can be used to remove midriaza caused gomatropinom; when midriaze of atropine and ìîäåëèðîâàíèå Aceclidine inadequate.

     Higher doses for adults under the skin : single 0.004 g (2 ml of 0.2% solution), the daily 0,012 g (6 ml of 0.2% solution).

     In therapeutic doses Aceclidine well tolerated. In some cases, when a solution in konyuktivalny bag may appear slight irritation close-vascular injection; Sometimes have unpleasant subjective sensations (lomota Mr. brunt of the eye). These phenomena are alone. Like other after mioticheskih funds, it is recommended after backfilling atseklidina press on March 2 minutes of lachrymal bag to prevent ingress of the solution in lachrymal canal and cavity nose.

     In overdose atseklidina (in the application by injection) or elevated individual sensitivity can be observed salivation, sweating, diarrhea and other phenomena associated with the initiation holinoreaktivnyh systems. These phenomena quickly kupiruyutsya of atropine, metatsina or other holinolitikov.

     Application atseklidina contraindicated in bronchial asthma, severe heart disease, strokes, krovotecheniyah from the gastrointestinal tract, epilepsy, giperkinezah, pregnancy (if the product is not appointed to improve the tone muscles uterus), as well as in inflammatory processes in the abdomen before surgical intervention.

     Method of issuance : powder (for the eye kapep); 0.2% solution for injecting in ampoules of 1 and 2 ml.

     Storage : A. In a list ukuporennyh banks orange glass; Solutions, in the dark place. Be careful to solutions for the eye drops were not used for injections.

     Rp : Sol. Aceclidini 3 ml 10%

     D.S. Eye drops. On 1 - 2 - 3 drops four times a day

     R p. : Sol. Aceclidini 1 ml 0.2%

     D.t.d. N. in ampull 6.

     S. At 1 ml under the skin

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