ATSETILTSISTEIN (Acetylcysteinum).

     N-Atsetil-L- cysteic.

     Synonyms : Bronholizin, Mukosolvin, A cetein, Ase t have lcysteine, A irbron,

     In roncholysin, Fluimucetin, Fluimucil, Inspir, M ucisol, ucofilin M, M u l with a ticum, ucomyst M, M ucosolvin, Racomex and others.

     White or white to slightly yellowish sheen crystalline powder with low specific smell. The easily soluble in water and alcohol; PH 20% aqueous 7, 0, 7, 5.

     Is tsisteina amino acid derivative (see), which acethyl cysteic difference is that one amino hydrogen replaced remaining acetic acid.

     NAC is an effective mukolitichesky (sekretolitichesky) t. Rat.

     Razzhizhaya sputum and increasing its volume, NAC facilitates its allocation; To extract, also reduces inflammatory effects.

     The operation is due to its ability to free sulfgid rilnyh groups break disulfidnye connection acid mucopolysaccharides may moles, which leads to depolarization mukoproteidov reducing viscosity and mucilages. The drug also sit Pus.

     Applied diseases of the respiratory system, soprovozhdayushihsya raised by the viscosity of the accession of purulent sputum infection (acute and hro not have bronchitis, pneumonia, bronhoektaziya, cystic fibrosis, etc.). Profi lakticheski appointed to prevent complications from the operations in the respiratory organs, as well as after endotrahealnogo narcosis. Recommended is also tomography for washing bronchial tree.

     The drug is effective in infectious allergic bronchial asthma, bacterial pneumonia, especially meningitis, bronchitis or nagnoivshimisya bronchiectasis. But in those cases, caution should be exercised in connection with the possibility of increasing bronhiolospazma. Oseltamivir trust diversity simultaneously Bronchiodialator drugs'.

     NAC applied by inhalation of 2 to 5 ml 20% solution of 3 - 4 times a day (for 15 - 20 min); Vnutritrahealno impose on 1 ml 10% solution of every hour (in the form of slow instillyatsii); For promyva a bronchus in clinical tomography using 5 - 10% solution. + Where it is not the solution of NAC by inhalation and vnutritrahealno (with respiratory tract injuries, coma, etc.), as well as the child practice medicine impose intramuscularly.

     Adults enter intramuscularly for 1 to 2 ml of 10% solution of 2 - 3 times a day; Infants at the rate of 10 - 15 mg / kg 2 times a day; Children older than 1 year to 0.5 to 1 ml 10% solution two times a day.

     The length of treatment depends on the nature and course of the disease; Generally treatment continues 1 - 2 weeks; When traheobronhite-3 - 4 days, in cystic fibrosis-7 - 10 days.

     If necessary, give intravenous medication. Dose Adult 0.5 g (10 ml of 5% solution). After 30-90 minutes after the easier Division of sputum, which removes dirt or asthmatics. Actions speak in a single dose Parata be 2 to 4 hours In exchange they treat imports to 10 ml of 5% solution of 2 times a day for 7 to 10 days.

     Children entering NAC mainly intramuscularly.

     The drug is usually well. In some cases, possible middle bass (primarily related to a specific smell drugs). Oste precautions should be observed by those inclined to bronhiolospazmu (in the former nastup events bronhiolospazma designate bronhorasshiryayuschie means).

     With caution should be used in NAC propensity to Le gochnym bleeding, liver disease, kidney, adrenal dysfunction.

     With long-term use should be controlled as liver, kidney and adrenal, check blood enzyme rates.

     Contraindications : individual Hypersensitivity, bronchi asthma without formal teaching sputum.

     When working with the drug should use glass receptacles, avoiding contact with metal and rubber (perhaps education advisory feeds with a characteristic smell).

     Mixing solutions NAC Solutions with antibiotics and about teoliticheskih enzyme inactivation is not desirable to avoid drugs.

     If necessary, can be added Bronchiodialator funds.

     Product type : 20% solution for inhalation in ampoules for 5 or 10 ml and 10% injection of 2 ml ampoules and 5% solution in 10 mL ampoules.

     Solutions-colourless liquid with a specific smell; PH 6, 8, 7, 8. After opening vials solution could be rosy pink coat up (that does not preclude their use). Solution of the vials opened for inhalation suitable for a period of 48 h.

     Storage : List B. In the dark spot in t O 'to 5' S.

     Rp. : Sol. Acetylcysteini 20% pro inhalationibus 5 ml N.20

     D.S. For the inhalation of 5 ml 3 times a day

     Rp. : Sol. Acetylcysteini 10% pro injectionibus 2 ml N. in ampull 10.

     D.S. For intramuscular injection of 2 ml, 3 times a day (adult)

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