AMINOKAPRONOVAYA ACID (Acidum aminocapronicum). e-Aminokapronovaya acid.

     Synonyms : Epsilon- aminocaproic acid As i Nachova ron, idum As a minocaproicum, A fibrin, A micar, A minocaproic ac id, A minocapron, racid Sarah, Sarah ramol, E psamon, Er sicapron etc.

     Clear crystals or a white crystalline powder with the smell and taste. The easily soluble in water, very little of alcohol; Gigroskopichen. Solutions are sterilized at a temperature of 100 + 'C for 30 min.

     Aminocaproic acid, a substance Setback fibrinolysis (see Fibrinolizin). Plasminogen Activators and blocking part of oppressing plazmina, aminocaproic acid can provide specific hemostatic effect in krovotecheniyah of increased fibrinolysis.

     Aminocaproic acid is also kininov inhibitor (biogenic polipeptidov formed in the body from globulinov-influenced kallikreina).

     Diluted malotoksichen. With normal kidney function rapidly (after 4 h) presented with urine.

     Applied to stop bleeding in surgical intervention and various pathologic conditions under which fibrinoliticheskaya increased activity of blood and tissue : after operations on the lungs, prostate, pancreatic and thyroid gland in premature aphykia normally situated placenta; The long delay in the uterus dead fetus; Liver diseases; acute pancreatitis; gipoplasticheskoy anemia and other acid aminokapronovuyu also impose massive blood transfusion is preserved if there is a possibility of development, secondary gipofibrinogenemii.

     Assign intravenously and inside. In moderately expressed increasing fibrinoliticheskoy activity inside to take 2 - 3 g 3 - 5 times a day; Powder dissolve in water or sweet ?high it. Daily intake is usually 10-1915 treatment course 6 to 8 days. For quick effect in acute gipofibrinogenemii injected sterile 5% solution of the drug on isotonic sodium chloride solution drip to 100 ml. If necessary, repeat injection of 4 h intervals, imposing on the city of 1

     Application aminokapronovoy acid solution can be combined with the infusion of glucose solution, Osteoporosis, protivoshokovyh solutions. In addition to impose severe fibrinolysis fibrin (see).

     In naznachnii acid aminokapronovoy be verified fibrinoliticheskuyu activity and blood content fibrinogena.

     Intravenous drug to produce a controlled koagulogrammy.

     Aminocaproic acid also has antiallergic activity oppresses education antibodies increases detoksikatsionnuyu liver function.

     In applying aminokapronovoy acid, in some cases, possible dizziness, nausea, diarrhea, mild catarrhal upper respiratory tract inflammation. The reduced dose side events usually take place.

     Contraindications to the use of acid aminokaprovoy are prone to thrombosis and embolism, kidney disease violation of the responsibilities of pregnancy.

     With caution should be applied in acid aminokapronovuyu violations of cerebral circulation.

     There have been reports of inappropriate use of acid aminokapronovoy women to prevent elevated krovopoter birth, the opportunity thromboembolitic complications in the postpartum period.

     Product : powder; In vials containing 100 ml of sterile 5% solution of isotonic sodium chloride solution.

     Storage : powder in a dark glass ukuporennyh banks in a cool, dry place; Bottles, with a temperature of 0 to + 20 'C.

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