NALIDIKSOVAYA ACID (Acidum nalidixicum). 1-methyl he Etil-7--1, 8-naftiridina-3- carboxylic acid.

     Synonyms : Nevigramon, Blacks (Trade name "Negro" from the word "gramnegativny) Cistidix, Nagram, Nalidin, Nalidixanum, Nalidixic acid, Nalidixin, Naligram, Nalix, Nalurin, Naxuril, Negram, Nevigramon, Nogram, Notricel, Specifin, Urodixin , Urogram, Uroneg, Wintomylon and others.

     The crystalline powder of light yellow color. Nerastvorim water.

     Is synthetic antibacterial drugs. Effective in infections caused by gram bacteria, coliform, and dysenteric bryushnotifoznoy wand, Protea, Klebsiella wand (Friedlander). There bakteriostaticheski and bactericidal. Also effective against strains resistant to antibiotics and sulfanilamidam. Ineffective against gram kokkov (staphylococci, streptococci, pnevmokokki) and pathogens anaerobov.

     The drug is well absorbed from the gastrointestinal tract. About 80% is allocated to the urine unchanged. The half was approximately 8 hours, but kidney failure is 20 hours or more.

     Applied mainly urinary tract infection routes (anesthetic, pielit, medicine), caused by susceptible to microbial products; The most effective for acute infection. Assign also for the prevention of infections from the operations in the kidneys and urinary bladder. Recommended if enterocolitis, cholecystites, pneumonia and middle ear infections caused by susceptible to microbial products, including resistance to other antibacterial means.

     Adults are inside of 0.5 g (1 1 capsule or tablet), and with more severe disease, and 1 g four times a day. The course of treatment is not less than 7 days. In long-term care apply to 0.5 grams, 4 times a day.

     Children appoint a rate of 60 mg / kg daily dose broken into 4 equal parts.

     Usually nalidiksovaya acid well tolerated; But the possible nausea, vomiting, diarrhea, headache, dizziness. There may be allergic reactions (dermatitis, increased body temperature, eosinophilia), as well as increased skin sensitivity to sunlight (photo).

     Patients who are in violation of cerebral circulation, parkinsonizmom epilepsy may have convulsions. In connection with the possibility of convulsions reactions should guard against drug overdose in children. Pronounced adverse reactions require temporary or eliminating drug.

     Contraindications violation of liver function, oppression respiratory centre. Much caution is needed when insufficient kidney function. Do not assign women in the first three months of pregnancy and children up to 2 years.

     It should not be used in conjunction with medication nitrofuranami, as this reduces antibacterial effect.

     Method of issuance : capsules or tablets of 0.5 g.

     Storage : List B.

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