ETMOZIN (Aetmozinum). Karbetoksiamino-10- 2 - (3-morfolinopropionil) - fenotiazina gidrohlorid7

     Synonyms: Ethmosine, Etmozin, Moracizin hydrochlorid.

     White or white with a touch of white crystalline powder. Soluble in water, it is difficult to alcohol. In light dark. Aqueous solutions for injection (pH 2, 5% solution of 3, 3, -4, 2) Prepare, filtering through sterilizuyuschy filter.

     On chemical structure is similar to aminazinom and production business fenotiazina. However adjunct activity etmozin not, and is an effective tool antiaritmicheskim.

     An important feature of the chemical structure etmozina, distinguishing it from nazina s and its analogues, is the presence in the side chain atoms with nitrogen etmozina propionilnoy Group (S-2-CH-CH 2) instead propilnoy (CH 2 CH 2 CH 2) by aminazina. In this regard etmozin close to the anti anginalnomu drug "Nonahlazin (see).

     Etmozin to antiaritmicheskim drugs group I (hinidino such action). It also provides modest koronarorasshiryayuschy, skin, M-holinolitichesky effect.

     Apply in ekstrasistoliyah, paroxysmal tachycardia and paroksiz stroke mertsatelnoy arrhythmia caused by IBS, as well as arrhythmia other etiology. Effective with arrhythmia caused by overdoses of cardiac glycosides. Comparative studies show that etmozin is a very effective drug in zheludochkovyh arrhythmia.

     Assign inside, intramuscularly or intravenously.

     When PVC are inside, starting with doses of 75 and 200 mg / day (25-50 mg 3 or 4 times a day). Predserdnye arrhythmia drug buy actors in smaller doses than zheludochkovye. If the effect is not developed, increasing the dose of 300 to 400 mg per day and, if sustained arrhythmia, and 600 mg / day (100 mg every 6 days) (In zheludochkovyh arrhythmia apply etmozina to 800 mg a day.) . Upon reaching the therapeutic effects of the drug continue to assign to support doses (reduced to the usual 1 / 3).

     The length of treatment depends on the form of arrhythmia, and the effectiveness of therapy and is usually 7 to 45 days.

     Admission etmozina interior can be combined with the introduction in his veins, or intramuscularly.

     For kupirovaniya attacks paroxysmal tachycardia product type intravenously or intramuscularly.

     Single dose for intravenous or intramuscular injection of 50-100-150 mg (2 - 4-6 2 ml, 5% solution). Daily dose should not exceed 600 mg.

     For vnutrimyshechnogo introduction razvodyat 2 2 - 4 ml, 6% solution etmozina in 1 - 2 mL of 0.25 - 0.5% solution of Novocaine. To introduce veins razvodyat 2 2 ml, 5% solution etmozina (50 mg) in 10 ml isotonic sodium chloride solution, or 5% glucose solution. Enter slowly for 5 to 7 minutes.

     With good portability etmozina dose can be increased to 4-6 2 ml, 5% solution (100-150 mg). If necessary (lack of effect in zobnovlenii arrhythmia) to impose an additional 3 times a day at intervals of 1, 5, 2 hours

     When you receive etmozina into possible in the pain of making small pieces gastralnoy area, light dizziness, skin itching; While intravenous a short-dizziness, lowering AD; When vnutrimy shechnom-local pain of making. Do not enter the drug under the skin (because of the irritant).

     Contraindications: severe handicaps in conducting system of the heart, vessels produce hypotension, as a violation of liver and kidney. It is time to appoint simultaneously monoaminoksidazy inhibitors; After ingibito ditch MAO needed a break (2 weeks).

     Method of production: tablets to 0.1 g in the package of 50 cards; 2, 5% solution in 2 ml ampoule in the package of 10 vials.

     Storage: List B. pills in a dry, sheltered from the world scene; Ampoule in sheltered from the world scene with a temperature higher than 10 C.

     When working with the drug must be taken, warning it into the skin and mucosal lining (see Aminazin).

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