ALFAKALTSIDOL (Alfacalcidol).
9, 10-Sekoholestatrien-5Z, 7 E, 10 (19) - diol - 1, 3.
Holekaltsiferol R H; R-OH-Oksidevit (oksiholekaltsiferol).
Synonyms : Alpha D3, Van Alpha, Oksivitamin D3, Oksidevit, Oksiholekaltsiferol, Etalfa, Alfa D3, Etalfa, One-Alfa, Oxidevitum, Oxycholecalciferol.
The structure and operation oksidevit close to holekaltsiferolu, ie vitamin D3.
Clear crystals or a white crystalline powder. Almost nerastvorim water, easily soluble in alcohol; Little slowly dissolves into sunflower oil.
Oksidevit is a natural metabolite of vitamin D said. Like other vitamins Group D oksidevit exchange regulates calcium and phosphorus stimulates their intake of reabsorption in the intestines and kidneys. Has a stronger antirahiticheskoy activity than ergocalciferol.
Applied with rickets and rahitopodobnyh diseases requiring correction pesticides limestone exchange imperfect kosteobrazovanii, osteoporosis and osteomalacia different backgrounds (including postmenopauzalnom, steroid osteoporosis, etc.), and renal diseases involving violations of vitamin D metabolism and mineral exchange.
Applied oksidevit inside regardless of meal times.
Children with the disease rahitopodobnyh designate 0,0005 - 0,003 mg a day, depending on age and body mass during 2 - 3 months to 1 year.
In rickets apply to 0,001 mg a day every day for 10 days. Perform three courses with two-week break between them.
When bone pathology (osteoporosis, osteomalacia) different genesis dose range from 0.0005 to 0.003 mg / day for a long time (from 2 - 3 months to 1 year or more).
In chronic renal failure (HPN) children who are hemodialysis, in order edema osteodystrophies appoint 0,001 mg per day, while use ergokaltsiferola to 2000 IU daily for a long time. Adult patients with HPN in hemodialysis, appoint 0,001 - 0,002 mg / day or every second day, followed by a decline to 0.0005 mg dose, depending on the normalization of calcium in the blood and alkaline phosphatase activity.
The course of treatment, dlyashiysya 2 - 3 months, it is recommended to repeat 2 - 3 times a year.
При ХПН требуется предварительная коррекция гиперфосфатемии.
Hospitalized after kidney transplantation preventative appoint 0,00025 - 0,001 mg / day or every second day.
Treatment oksidevitom must be under constant supervision of calcium and phosphorus in the blood, and the activity of alkaline fosfotazy (with a weekly monitoring HPN).
Like vitamin D, oksidevit in doses exceeding their physiological needs, can have toxic effects. Препарат токсичнее витамина D, однако в отличие от него не накапливается в организме, а подвергается быстрому катаболизму и выведению, поэтому при прекращении поступления препарата гиперкальциемия обычно проходит самостоятельно.
In applying the drug may allergic reactions.
Oksidevit contraindicated in patients giperkaltsiuriey (urolitiasis). In the case of development in the treatment of the phenomenon of drug giperkaltsiurii admission stop, and then designate in small doses.
Method of issuance : Capsule to 0,001; 0.0005 and 0.00025 mg.
Storage : List B. In dry, the dark place at a temperature no higher than 10 C.
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