ALLAPININ (Allapininum).

     Gidrobromid alkaloid lappaconitine (with some impurities other related alkaloids), derived from herbs Aconitum (champion) beloustogo Aso nitum leucostomum Worosch. , Herewith. hares (Ranuncul aseae).

     White or white with a slightly kremovatym white crystalline powder. Little is soluble in water.

     Lappakonitin-[1 a, 14 a, 16-b trimetoksi-4- (N-acetyl-antranoiloksi) -8, 9-N etil-18- norakonan].

     The drug has antiaritmicheskoe effect. Referring to the complications of I group. Wrinkles an institution for predserdiyam, beam Gisa and Purkinje fibers. It has significant negative inotropnogo action, it is arterial hypotension.

     When applied nadzheludochkovoy and ventricular arrythmia, epileptic, oils and flicker predserdy, nadzheludochkovoy and paroxysmal ventricular tachycardia, as well as adults in the face of myocardial infarction.

     Assign inside, intravenous and intramuscular injection.

     Inside are 30 minutes before eating, squeezed warm water. Pills advise chop. First appointed to 0.025 g every 8 hours In the absence of effective dose increases, the supply of 0,025 g every 6 hours Perhaps a further increase in dose to 0.05 g per reception every 6 to 8 hours The length of treatment depends on the condition of the patient and the nature of the disruptions and may last up to several months.

     Higher doses when administered : single 0.15 grams daily 0.3 g.

     Early action when administered after a single reception-40 60 minutes, a maximum of 4-by-5 h, the total length of more than 8 h.

     VFS give intravenous dose of 0.3 - 0.4 mg / kg. Before applying the product to grow 20 ml isotonic sodium chloride solution. VFS impose slowly for 5 minutes. If necessary after 6 h in a drug dose 0.3 mg / kg repeat.

     When a drug intravenously, a relatively slow-through 15 - 20 minutes and reaches a maximum at 2 th hour; The long-term effect remains to 6 to 8 h. (Perhaps it is a matter of education and the accumulation of metabolites.)

     Intramuscularly VFS give dose of 0.4 mg / kg every 6 h

     In applying allapinina possible dizziness, headache, feeling of heaviness in the head, hyperemia person diplopia. In appearance these phenomena, drug dose should be reduced. Sometimes there are allergic reactions.

     The drug is slowing vnutrizheludochkovoy conductivity. Could have aritmogennoe effect. Perhaps the emergence sinusovoy tachycardia.

     Contraindications : atrioventrikulyarnaya blockade II degree and post-graduate levels, severe liver and kidney failure. When I atrioventrikulyarnoy blockade extent violations vnutrizheludochkovoy conductivity, weakness sinusnogo node syndrome, as well as severe circulatory failure, VFS should be appointed by a careful medical supervision, starting treatment in a hospital and more exercise EKGkontrol. Pregnant VFS appoint only emergencies.

     Method of issuance : pills to 0,025 g (25 mg); 0.5% solution in ampoules of 2 ml (10 mg) in a package of 10 vials.

     Storage : List B. In the dark spot (pill-dry).

Materials allowed to copy only with the active hyperlink to the handbook of medicines