ALLOPURINOL (Allopurinolum). Oksipirazolo 4-[3 4-d] Pyrimidine.

     Synonyms : Milurit, Allopur, Allopurinol, Apurin, Atisuril, Foligan, Goticur, Lysurin, Milurit, Petrazine, Prynol, Pyral, Purinol, Uridozid, Uriprim, Xanturat, Zylapour, Zyloprim, Zyloric and others.

     White or white with kremovatym nuance melkokristallichesky powder. Almost nerastvorim in water and alcohol.

     The drug has a specific enzyme inhibition ability ksantinoksidazu involved in making gipoksantina in ksantin and ksantina acid in the urine. In this regard, education uratov decreases in serum and avoided their deposits in the tissues and the kidneys. Allocation of uric acid in urine decreased and increased allocation gipoksantina and ksantina.

     Allopurinol applied to the treatment and prevention of diseases involving giperurikemiey : with gout (primary and secondary), caused illness (with education uratov), primary and secondary giperurikemii occurring in diseases involving enhanced dissolution nukleoproteidov and increased uric acid in the blood, as Among the various gematoblastomah (acute leukemia, chronic mieloleykoze, lymphosarcoma, etc.), with cytostatic and radiation therapy of cancer, psoriasis, as well as the massive corticosteroid therapy drugs, when intense dissolution tissues significantly increases the number purinov blood, which can lead to mochekisloy nephropathy defeat kidney function.

     Is allopurinol inside (after eating). Dose set depending on the content of uric acid in the blood. The minimum therapeutic dose of 0.1 grams per day, maximum 0,8 city usually at a moderate (10 mg%) giperurikemii take on the 0.2 - 0.4 g / day for 2 to 3 weeks, then move on to supporting dose 0.2 - 0.3 g / day (2 - 3 admission).

     In severe cases, gout, with significant deposits in the tissues and uratov giperurikemii high (above 7 mg%) to designate 0.6 - 0.8 g explored (no more than 0.2 g per reception) within 2 to 4 weeks, then move on to support doses (0.1 - 0.3 g / day), which offer long-term (several months).

     When a reception allopurinola urikozuriya Friday and returned to the 3 - 4-day to the original, so treatment should be extended. The gaps in reception drug over 2 to 3 days undesirable.

     To prevent giperurikemii with radiation therapy and chemotherapy tumors appoint an average of 0.4 g / day; Take medication for 2 to 3 days before the start of treatment, or both, and continue for several days after a specific therapy.

     There are performance allopurinola adjuvant therapy in children with epilepsy. I think that the effect is due to the inhibiting influence of drugs triptofanpirrolazu and increase serotonin biosynthesis. Applied allopurinol (in addition to antiepileptic means) in the dose of 4 to 5 mg / kg 2 times a day, 10-day course with a time 1 -2 5 months.

     The drug is usually well. When treating gout at the beginning of the course may be worsening because of the mobilization of uric acid from scrophulosis door and other tissue depots. Some patients may diarrhoeal phenomenon, skin rashes, lowering body temperature, eosinophilia.

     Be sure to watch nerezko expressed patients with renal failure : the dose does not exceed 0.2 grams per day.

     When treating allopurinolom Diurez needs to be maintained at no less than 2 litres per day; It is desirable that the reaction of urine was neutral.

     Allopurinol is contraindicated in pregnancy and renal failure.

     If allopurinola gematoblastom therapy in the treatment of drug (mercaptopurine, methotrexate, etc.) should keep in mind that allopurinol oppresses enzimaticheskoe oxidation of the products and makes them antitumor activity, but significantly increases their toxicity, and therefore doses of the drug therapy must be reduced (50%).

     There should be appointed along with allopurinol preparatyami iron.

     Product : 0.1 grams of pills in a package of 50 and 100 pieces.

     Storage : List B. In the dark spot.

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