ALTEPLAZA (Alteplase).
Synonym : Aktilize, Actilise.
Tissue plasminogen activator-enzyme (glikoprotein) sinteziruyuschiysya in mammalian tissues that can turn plazminogen in plazmin (in the presence fibrinogena) inside and on the surface of blood clot.
From a culture of human cells.
Tromboliticheskoe of alteplazy (as streptokinase and urokinazy) lasts about 4 hours, reperfuziya attack is 20 minutes to 2 h after intravenous injection.
Compared with other fibrinoliticheskimi drugs (in particular with streptokinase) alteplaza operates on Thrombus more selective, has a short half (4.5 min) and no antigenic properties that can apply it again, including in patients previously receiving streptokinase .
Like other tromboliticheskim alteplaza drugs in dosage of hemorrhagic complications is often limiting the possibility of widespread use.
Alteplazu tromboliticheskoy applied to therapy in the first 12 h after myocardial infarction, and acute massive pulmonary embolism.
Enter intravenously. The contents of two bottles (0.1 g) in giving a dissolve in 100 ml of water for injection. In the first six hours of the start of myocardial infarction introduce 0,015 grams (0.01 grams in a period of 6 to 12 h after the onset) of bolyusa for 1-2 minutes, then infuzionno 0.05 grams (about 0 75 mg / kg) for 30 minutes (60 minutes in the period from 6 to 12 h) and the remaining 0,035 grams (about 0.5 mg / kg) for 60 minutes (for the period from 6 to 12 h 0 01 grams per 30 minutes up to a total dose of 0.1 g for 3 h). When pulmonary embolism impose 0.01 grams of bolyusa and then infuzionno 0.09 g for 2 hours After starting the introduction of the drug heparin (5000 IU of bolyusa then infuzionno to 1000 IU per hour).
Precautions, possible complications and contraindications such as when applying fibrinoliticheskih other drugs (see Streptokinase).
Product : dried powder for injection solutions in bottles of 0.05 g complete with solvent).
|
||
Materials allowed to copy only with the active hyperlink to the handbook of medicines
|
||
