ALTRETAMIN (Altretamin).

     N, N, N? N? N? ? N? ? - Geksametil-1, 3,5-triazine - 2, 4,6 - triamine.

     Synonym : Geksalen, Hexalen.

     The white crystalline powder. Almost nerastvorim water and propylene, well soluble in chloroform, ethyl and N, N-dimethylformamide.

     By forming covalent with macromolecules, including RNA and DNA, preclude the inclusion timidina in DNA.

     Quickly and completely absorbed in the digestive tract, A max is 0,5-3 h, T? (Phase allocation) 4,7-10,2 h; biotransformation are in the liver, kidneys displayed.

     Applied with ovarian cancer (sustained by cisplatin and alkiliruyuschim drugs) and melkokletochnom cancer light.

     Assign inside (after eating) to 0.26 g / m 2 per day (4 admission) for 1, 2 or 3 weeks at intervals of 1-4 weeks.

     Possible side effects : diarrhoeal phenomenon, stomatitis, pitting mucosal of the oral cavity, disruption of the liver, moderate leyko- and thrombocytopenia, anemia (rarely), peripheral neuropathy, apnoea reaction.

     Contraindications : neurological disorders, pregnancy, breast-feeding, childhood.

     Product : Capsule to 0.05 g (50 mg) (N. 10, 40, 60, 80).

     Storage : List B.

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