AMINALON (Aminalonum). g-Aminomaslyanaya acid.

     Synonyms : Gammalon, Ganevrin, Apogamma, Encefalon, GABA, Gaballon, Gamarex, Gammalon, Gammaneuron, Gammar, Gammasol, Mielogen, Mielomade and others.

     The white crystalline powder with slabogorkim taste and low specific smell. The easily soluble in water, very little is soluble in alcohol; PH 5% aqueous 6, 5, 7, 5. g-Aminomaslyanaya acid (GABA) is a nutrient substances. Contained in the central nervous system and is involved in neyromediatornyh and metabolic processes in the brain.

     It was found that GABA is the main mediator involved in the processes of the central braking.

     Influenced GAMK energy processes also activated brain activity increased respiratory tissue, improves brain glucose utilization, improved blood circulation.

     Effects of GABA in the CNS is through its interaction with specific receptors GAMKergicheskimi who recently GAMK- divided into A and B receptors GAMK- and others mechanism of action of a number of central neurotropic substances (sleeping pills, convulsants, of convulsions, etc.) essential their agonisticheskoe or antagonistic interactions with GAMK- receptors. A close relationship between GAMKergicheskimi and benzodiazapine receptors. Benzodiazipines potentsiruyut of GAMK.

     GAMK presence in the CNS was discovered in the mid 50-s, it was soon synthesis. In the late 60 years, entitled <<Gammalon>> GAMK was proposed for use as medicines abroad, then called <<Aminalon>> in our country.

     The experimental data, GAMK in giving body poorly crosses the blood-brain barrier. However, the GAMK to treatment with cerebral pathology found that it improves the performance of nerve in the brain, thinking, memory, has a mild stimulating effect.

     As drug use acid found mainly in geriatric practices and the treatment of children with mental retardation. The nature of the therapeutic drug approaching neuroprotective means. The effect of moving slowly, a relatively long course of its application. Despite the emergence of new neuroprotective drugs, which in some cases more pronounced effect (pyracetam, etc.), acid therapeutic value lost.

     Applied acid in the brain vascular disease (atherosclerosis, hypertension), in chronic violation tserebralnososudistoy insufficient memory, attention, speech, dizziness and headaches, the dynamic violations of cerebral circulation, as well as after a stroke and brain injuries to improve motor and mental activity patients. There are performance aminalona with endogenous depression dominated astenoipohondricheskih events, and difficulty thinking. The drug can also be used in alcoholic encephalopathy, alcoholic polinevritah, dementia. Children acid used in the development of mental retardation with reduced mental activity.

     Gamma-aminobutyric acid are inside (to food) to 0.25 g. Adults appointed depending on the nature and severity of the disease at 0.5 to 1, 25 g three times a day. Daily intake typically 1, 3, 5-city children, depending on age are from 0.5 to 3 grams per day. The course of treatment lasts from 2 to 3 weeks to 2-6 months. If necessary, a second course of treatment.

     For syndromic treatment motion acid designate an adult to 0.5 g and 0.25 g for children 3 times a day for 3 to 4 days. From objective adult appointed to 0.5 g three times a day during the three days preceding the possible motion and the same dose directly to the use of transport.

     Gamma little toxic. Well transferred patients of various ages. In some cases, possible diarrhoeal phenomenon, sleeping, feeling heat, blood pressure fluctuations (in the early days of treatment). In reducing doses of these phenomena are usually quickly pass.

     Product : pills to 0.25 g-coated (white or white with kremovatym bit colour), in a package of 100 pieces.

     Storage : dry, the dark spot.

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