AMINAZIN (Aminazinum). Hlor-10- 2 - (3-dimetilaminopropil) - fenotiazina hydrochloride.

     Synonyms : Plegomazin, Chlorpromazine, Ampliactil, Amplictil, Chlorazin, Chlorpromazini hydrochloridum, Chlorpromazine hydrochloride, Chlorpromazine, Contomin, Fenactil, Hibanil, Hibernal, Kloproman, Largactil, Megaphen, Plegomazin, Promactil, Propaphenin, Thorazine and others.

     White or white with weak melkokristallichesky cream flavor powder. Slightly gigroskopichen. Night Light. Very easily soluble in water. Powder and aqueous solutions of age under the influence of light. Solutions are acidic reaction; PH 2, 5% solution of 3, 5, 5, 5.

     Sterilization water solutions can be made from + 100 C for 30 minutes, but they do not usually sterile, as they have bactericidal properties.

     Solutions aminazina (fenotiazinovyh and other products) are incompatible with solutions barbiturates, carbonate, a solution Ringera (sedimentation).

     Aminazin is one of the main representatives Neuroleptics. Despite the emergence of many new neyrolepticheskih products, it continues to be widely used in medical practice.

     One of the main features of central nervous system aminazina at a relatively strong sedative effect. The increasing with the increase in the total dose aminazina comfort uslovnoreflektornoy by oppression and above all dvigatelno- defensive reflexes, less spontaneous locomotor activity and some relaxation skeletal muscles; State is reduced reactivity to endogenous and exogenous incentives; Consciousness, however, remains. In high doses, can develop state of sleep.

     Aminazin aggravating hypnotics, narcotics, analgesics, mestnoanesteziruyuschih substances. It oppresses different interotseptivnye reflexes.

     Step convulsants funds under the influence aminazina increase, but in some cases may cause apnoea aminazin phenomenon.

     The drug has a great effect and soothes protivorvotnoe ikotu (see also Etaperazin).

     Aminazin has gipotermicheskoe effect, especially when artificial cooling the body. In some cases, in patients with a parenteral drug body temperature is rising because of the impact of centres of thermal and partly with the local irritant effect.

     The drug has also moderate anti properties, reduces vascular permeability, and reduced activity kininov gialuronidazy. Has antigistaminnoe little effect.

     Aminazina An important feature is its impact on the central locking and adrenergicheskie dofaminergicheskie receptors. It reduces or completely eliminates the increase AD and other effects caused by adrenaline and adrenomimeticheskimi substances. Giperglikemichesky effect via aminazinom not withdrawn. Very central expressed adrenoliticheskoe effect. Key influence on holinoretseptory expressed relatively weak. The drug has a great effect kataleptogennoe.

     Blood pressure (systolic and diastolic) by aminazina lowered, often developed tachycardia.

     The main features are its aminazina antipsihoticheskoe operation and ability to influence the emotional sphere rights. Through aminazina able nausea various psychomotor stimulation weaken or completely crazy nausea and hallucinations, reduce or remove fear, anxiety, stress in patients with psychosis and neurosis.

     In psychiatric practice aminazin used in a variety of psychomotor bringing in patients with schizophrenia (gallyutsinatornobredovy, schizophrenia, Catatonia syndromes), and chronic paranoidnyh gallyutsinatorno- paranoidnyh state, Manic bring in patients with manic depressive, and Psychotic disorders in patients with epilepsy, and depression azhitirovannoy in patients presenilnym, manic depressive, as well as other mental health and neurosis involving initiation, fear, insomnia, stress, in acute alcoholic psychosis.

     Aminazin can be used independently or in combination with other psychotropic drugs (antidepressants, butirofenona derivatives, etc.).

     Features of aminazina able to bring over other Neuroleptics (triftazin, haloperidol, etc.) is pronounced sedative effect.

     In practice aminazin neurological diseases also nominated, along with increased muscle strength (after brain insulta etc.). Sometimes used for edema epileptic status (with the ineffectiveness of other treatments). Enter it for that purpose intravenously or intramuscularly. Note that in patients with epilepsy aminazin may cause frequent fits, but usually in conjunction with the appointment convulsants drugs it makes to the latter.

     Effectively use aminazina combined with analgesics with persistent pain, including kauzalgii, and the drugs and tranquilizers, with hard insomnia.

     As protivorvotnoe tool sometimes used aminazin with vomiting during pregnancy, disease Menera in oncological practice in the treatment hloretilaminami and other chemotherapy drugs, and radiation therapy. The clinic skin diseases can be used in zudyaschih Medicine and other diseases.

     In practice anaesthetics aminazinom previously widely used for sedation and potentsirovannogo narcosis. Increased aminazinom of drugs and analgesics can significantly reduce their dose; It also increases the effects of muscular Ward. With artificial hypothermia aminazin to lower body temperature. Usually aminazin used for this purpose, together with other neurotropic medications (the so-called political mixture).

     Political mixtures contain along with aminazinom protivogistaminnye drugs (Promethazine, dimedrol, etc.), analgesics (promedol or others), for example : aminazina 2, 5% solution of 1 - 2 mL diprazina 2, 5% solution of 2 ml, promedola 2% solution 1 ml or aminazina 2, 5% solution of 1 - 2 ml, dimedrol 2% solution of 2 ml, promedola 2% solution of 2 ml. Mixtures of these type intramuscularly or intravenously.

     Recently anesthesiological practice increasingly used mixtures containing Droperidol (see), in combination with analgesics and other neurotropic means. But political mixtures containing aminazin, are not lost.

     Assign aminazin inside (in the form of pills), intramuscularly or intravenously (in the form of 2, 5% solution). In a parenteral effect is faster and more pronounced. Inside drug is recommended after eating (to reduce irritants in the mucous membrane of the stomach). In intramuscular introduction to the amount of solution aminazina add 2 to 5 ml of 0.25 - 0.5% solution of novocaine or isotonic sodium chloride solution. Solution impose deep in the muscles (in the upper outer quadrant of rump or naruzhnobokovuyu surface of the thigh). Intramuscular injections to no more than 3 times per day. For intravenous solution aminazina necessary to throw in the 10-20 ml of 5% (some 20-40%) glucose solution or isotonic sodium chloride solution, introducing slowly (over 5 minutes).

     Dose aminazina depend on the way the introduction of evidence and the age of the patient. The most convenient and frequent reception is aminazina inside.

     When treating mental illness initial dose is usually 0,025 - 0,075 grams per day (1 - 2 - 3 admission), then gradually increased to a daily dose of 0.3 - 0.6 d. In some cases, a daily dose of ingestion reaches 0.7 g -1 (particularly in patients with chronic disease and mental institute). The daily dose in the treatment of large doses divided into four parts (in the morning, afternoon, evening and night). Duration of treatment big dose should not exceed 1 - 1 5 months, with little effect to move to other treatment drugs. Prolonged treatment of a aminazinom being relatively rare. Most aminazin combine with triftazinom, haloperidol and other drugs.

     With a daily dose intramuscular aminazina generally should not exceed 0.6 g. On reaching effect on the admission of drug moving inside.

     By the end aminazinom treatment, which can last from 3 to 4 weeks to 3 to 4 months and longer, gradually lower the dose of 0,025 to 0,075 grams per day. Patients with chronic disease designate long supportive therapy.

     In terms of psychomotor excitation primary dose of intramuscular introduction is usually 0.1 - 0.15 g. To initiate emergency acute edema can enter aminazin in vein. This 1 or 2 2 ml, 5% solution (25-50 mg) aminazina to throw in 20 ml of 5% or 40% glucose solution. If necessary, increase the dose aminazina 2 to 4 ml, 5% solution (40 ml glucose). Enter slowly.

     In acute alcoholic psychosis designate 0.2 - 0.4 g / day aminazina intramuscularly and inside. If the effect is insufficient, intravenously injecting 0.05 - 0,075 grams are combined with levomepromazinom).

     Higher doses for adults inside : single 0.3 g daily 1, 5 g; Intramuscularly : single 0.15 g, 1 g daily; In vein : single 0.1 g daily 0.25 g.

     Children aminazin designate smaller doses; Depending on the age of 0.01 - 0.02 to 0.15 - 0.2 g / day, weak and elderly patients to 0.3 grams per day.

     To treat diseases of internal organs, skin and other diseases aminazin appointed in lower doses than in psychiatry (0,025 g for 3 to 4 times a day for adults; Older children - to 0.01 g per reception).

     When treating aminazinom could experience side effects associated with the local and Eferent of it. Trapped solutions aminazina under the skin, the skin and mucous membranes can irritate tissue; Introduction muscles often accompanied by a painful infiltrates; In giving veins may damage endoteliya. To avoid these phenomena solutions aminazina manage solutions novocaine, glucose, isotonic sodium chloride solution.

     Injecting a aminazina could trigger a sharp reduction in AD. Hypotension can develop and use oral drug, particularly in patients with hypertension; Aminazin these patients must designate in small doses.

     After injection aminazina patients should be placed in the position of lying (1, 5, 2 h). Rise slowly, without sudden movements.

     After receiving aminazina observable manifestations of allergic skin and skin irritation, facial swelling and limbs, as well as skin photosensitization.

     When ingestion possible diarrhoeal phenomenon. In connection with aminazina inhibiting effect on motor gastrointestinal tract and the secretion of gastric juice recommended the appointment of a drug to patients with bowel and atony ahiliey give a gastric juice or hydrochloric acid, and follow the diet, and gastrointestinal function.

     Sometimes the appearance of jaundice, agranulotsitoza, skin pigmentation. In foreign literature describe turbidity aphykia and cornea after a longer period (years) receiving large doses of the drug (0.5, 1, 5 g per day).

     In applying aminazina relatively developed neuroleptic syndrome, in a phenomena parkinsonizma, akatizii, indifference, a belated reaction to external and other mental changes. Sometimes there is a long follow-depression. To reduce the phenomena of depression using CNS stimulants (sidnokarb). Neurological complications are reduced when lower doses; They can also reduce or nausea while supplies tsiklodola, tropatsina holinoliticheskih or other means used to treat parkinsonizma. In developing dermatitis, severe face and limbs designate antiallergic funds or abolish treatment.

     Aminazin contraindications to liver damage (cirrhosis, hepatitis, Hemolytic jaundice, etc.), the kidneys (nephritis), as a violation of blood-forming organs, miksedeme, progressive systemic diseases, the brain and spinal cord, urological defects heart tromboembolicheskoy disease, as well as patients in the late stages Bronchoectatic disease. The relative contraindications are zhelchnokamennaya, ìî÷åêàìåííàÿ disease, acute pielit, rheumatism, heart. In gastric ulcer and duodenal ulcers should not appoint aminazin inside (enter intramuscularly). Do not appoint aminazin (as well as other drugs fenotiazinovye) persons in a coma, including in cases involving the admission of barbiturates, alcohol, drugs. It should monitor blood picture, including protrombina index, the study of liver and kidney function. Aminazin not apply to proceedings in acute edema of brain injury. There should be appointed aminazin pregnant.

     Method of issuance : Bean to 0,025; 0.05 and 0.1 g 2, 5% solution in ampoules to 1; 2; 5 and 10 ml. Also produced pills aminazina to 0.01 g-coated (yellow), children (Tabulettae aminazini 0.01 obductae pro infantibus) in banks to 50 pieces.

     Storage : List B. Banks dark glasses, tightly closed congestion, filled with paraffin, in a dry, the dark spot. Beans, tablets and capsules, in the dark place.

     Rp. : Dragee Aminazini 0,025 N. PC

     D. S. At 1 pills 3 times a day after meals

     Rp. : Sol. Aminazini 2, 1 ml 5%

     D.t.d. N. 6 in a m p ull.

     S. For intramuscular injection; Assigned to 5 ml 0.5% solution of novocaine

     Rp. : Sol. Aminazini 2, 5% 2 ml

     D.T. d. N.6 in ampull.

     S. For intravenous infusion of 1-2 mL; Previously assigned to 20 ml of 5% glucose solution

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