AMIODARON (Amiodaronum) *. [2 Butil-3- benzofuranil] - [4 - (2-O aminoetoksi) -3, 5-diyodfenil] ketone hydrochloride.

     Synonyms : Kordaron, Palpitin, A mjodaronum, A ngoron, A tlansil, rdaron So, So rdinil, Ra lpitin, Se dacoron, T rangorex etc.

     City is the main representative of complications drugs III.

     Amiodarone was originally proposed as koronarorasshiryayuschego (antianginalnogo) for the treatment of chronic forms of IBS. Further complications were identified its properties and is now widely used as a highly efficient antiaritmicheskogo drug. However, as a means antianginalnoe amiodarone are not lost.

     Antianginalnoe of amiodarone is partly due to his apparent (sosudorasshiryayuschim) and antiadrenergicheskim action. He has a braking effect on the a and b-adrenoretseptory cardiovascular system without causing complete their blockade. However, it raises the tone of the sympathetic nervous system. The drug reduces the resistance of the coronary vessels and increases coronary blood flow, reducing urezhaet heart, reduces the need for hospitalization, oxygen, increases energy reserves attacks (kreatininsulfata content increases, adenosine and glycogen). He slightly lowers peripheral vascular resistance and AD Systems.

     Unlike drugs, completely blocking b-adrenoretseptory, amiodarone virtually no negative inotropnogo action.

     Like several other antianginalnyh drugs have in varying degrees antiadrenergicheskoy activity, amiodarone reduced sensitivity to giperstimulyatsii sympathetic nervous system.

     The drug has expressed impact on the Electrophysiology processes attack. It significantly lengthens the potential of cardiomyocytes and thus increases the effective period refrakterny predserdy, Poly, predserdno- ventricular node beam Gisa and Purkinje fibers, as well as additional ways to pursue it. It can also slow down (diastolic) cell membrane depolarization sinusnogo hub and other cardiomyocytes and directly influence the mechanical heart. These and other properties of amiodarone for his efficiency in various departments, giving rise to it in a special (III), a group of drugs complications.

     City when administered slowly absorbed. Detection of blood through the 1 / 2 to 4 hours The maximum concentration in the blood there after 5 to 6 hours

     Write from the body extremely slowly, the half is 30 days or more. With the continued use of the drug accumulates in the body (cumulative).

     The beneficial effects are usually in a few days from the start of the reception, and reaches a maximum at 2 to 4 weeks. In high doses, the effect may come sooner.

     As antianginalnoe tools used in the chronic pain syndrome IBS (voltage and the rest); Preparation is more effective in patients with strokes voltage, especially when events giperstimulyatsii sympathetic nerve. Therefore, the effect of amiodarone, a drug shown, the combination of strokes with heart rhythm irregularities.

     There are indications that amiodarone in acute myocardial infarction period reduces the damaged area (on the EKG).

     When strokes designate amiodarone inwards in the form of tablets, starting with the usual dose of 0.2 g 2 - 3 times a day (during or after eating); Through Aug 15 days to reduce its 0.2 g 1 - 2 times a day.

     As antiaritmicheskoe means amiodarone has been in wide use in supraventrikulyarnoy paroxysmal tachycardia (especially related to the syndrome, Wolff - Parkinson-White), sinusovoy tachycardia, predserdnoy arrythmia, predserdy fibrillation, ventricular tachycardia, ventricular arrythmia. There is evidence that the drug is effective in parasistolii.

     High efficiency amiodarone can lead to prolonged use in patients with zheludochkovymi tahiaritmiyami with increased risk of sudden death.

     In the absence of negative inotropnogo of amiodarone can be appointed to congestive heart failure.

     Predserdiya more chuvstvitlny to action amiodarone, and supraventrikulyarnyh keep its effect is the earliest and more protracted than zheludochkovyh adults.

     For acute edema violations rhythm, drug injected normally at the rate of 5 mg / kg (enter slowly in 250 ml 5% glucose solution); If necessary, make repeated Infusion after 24 hours

     Inside is appointed, usually from 0.2 g (1 tablet) 2 - 3 times a day (0.4 - 0.6 g / day). In 5 - 8-15 days (depending on the effect) to reduce the dose of 0.4 - 0.3 g / day, then move on supportive therapy for the 0.3 -0.2 g (1, 5 - 1 tablet) day (2 admission).

     Is preparation before eating. Treatment usually spend long. To avoid the phenomenon of cumulation amiodarone are 5 days a week with two days break.

     Optimal dose must choose individually in the light of possible side effects.

     When taken amiodarone possible nausea, a feeling of heaviness in the stomach, nausea allergic seldom-muscle weakness, tremor.

     In overdose individually and sensitivity (especially the elderly), can develop aetiology (50 cuts per minute). It temporarily lift the product.

     Be careful when sharing with amiodarone therapy group lapidary to avoid the aetiology.

     It is possible aritmogennogo action.

     With a long reception amiodarone some patients are pigment deposits (lipofustsina) in the cornea, coated eyes, a brilliant rings, if the patient looks at the light source, skin pigmentation. In addition, there may be specific patologicheske changes in the lungs (fibrous alveolitis, interstitial pneumonia), manifested in the form of dry cough, breathlessness up to sometimes raise body temperature and other Rentgenologicheski identify sources of scattered light intensity changes. Most of these phenomena observed in long-term use of large doses of the drug. With long-term use amiodarone to periodically study X-ray light.

     It should be borne in mind that amiodarone molecule contains 37% iodine, and therefore may influence the metabolism of thyroid hormones to the development of events hypo - or hyperthyroidism.

     Contraindications : aetiology with a frequency of heart in less than 60 minutes, pregnancy and lactation period. Caution is needed when violations atrioventrikulyarnoy conductivity and bronchial asthma.

     Method of issuance : white pills for 0.2 grams in a package of 60 pieces; 5% solution in ampoules of 3 ml (150 mg).

     Storage : List B. In the dark spot.

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