AMITRIPTILIN (Amitriptylinum). 5 - (3-Dimetilaminopropiliden) -10,11 - digidrodibenzotsiklogepten.

     Available as hydrochloride (Amitriptylini hydrochloridum) :

     Synonyms : Teperin, Triptizol, Amitriptyline, Adepril, Adepress, Amiprin, Atryptal, Damilen, Daprimen, Elatral, Elavil, Lantron, Laroxal, Laroxyl, Lentizol, Novotriptyn, Proheptadien, Redomex, Saroten, Sarotex, Teperin, Triptizol, Triptopol, Triptyl, Tryptanol, Tryptizol and others.

     Amitryptiline like imipraminu, is one of the main representatives of antidepressant drugs. By setting different from imipramina that the nitrogen atom in the central part of tritsiklicheskoy replaced carbon atom.

     Is inhibitor reverse takeover neyronalnogo mediator monoaminov, including Levophed, dopamine, serotonin and other Ingibirovaniya MAO is.

     A large holinoliticheskaya activity.

     Timolepticheskoe combined effect of amitriptyline with the expressed sedative effect.

     Applied mainly endogenous depression. Especially effective for anxiety-depressive condition; Reducing anxiety azhitatsiyu own depressive symptoms.

     It is the deterioration of delirium, hallucinations and other productive symptoms that may, in applying antidepressantov- stimulants (imipramina etc.).

     Assign inside, intramuscularly or veins. Inside are (after eating), from 0.05 - 0,075 grams (50-75 mg) a day, and then gradually increase the dose to the 0,025 - 0,05 g to obtain the desired effect of antidepressant. The average daily intake of 0,15 - 0,25 g (150-250 mg) for 3 to 4 admission (during the day and at night). Aspirin-resistant effect gradually reduce the dose. In severe depression designate up to 300 mg (or more) a day.

     In severe depression can start with the introduction of the drug intramuscularly or intravenously (introduced slowly!) In dose 0,02 - 0,04 g (20-40 mg), 3 to 4 times a day. Injection drug gradually replace reception inside.

     Older patients preparation designate smaller doses; Children reduce the dose in accordance with the age.

     Amitryptiline is relatively common in somatic medicine with depression and neurotic condition. Assign inside a relatively low dose (0.0125, 0.00625 grams = 1 / 2 to 1 / 4 tablet).

     Amitryptiline usually well. Because of the sedative effect does not violate sleep, and he was appointed throughout the day, including at night. However, due to the effect holinoliticheskogo admission amitriptyline could experience dry mouth, increased pupil, a violation of accommodation, delay urination, as well as drowsiness, dizziness, tremor hand parestezii, allergic reactions, heart rhythm violation.

     Amitryptiline as preparation expressed holinoliticheskoy activity is not suitable for glaucoma, the isolationist prostate gland, bladder atony. It should not be appointed while monoaminoksidazy inhibitors.

     Method of issuance : pills to 0,025 g (25 mg); 1% solution in ampoules of 2 ml (20 mg).

     Storage : List B.

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