AMIZIL (Amizylum). 2-Dietilaminoetilovogo benzilovoy acid ester hydrochloride.
Synonyms : Benaktizin, Actozine, Amitakon, Benactina, Benactyzine, Benactyzinum, Cafron, Cevanol, Lucidil, Nervatil, Neurobenzile, Parasan, Phobex, Procalm, Suavitil, Tranquilline and others.
The white crystalline powder. Mg in the water, it is difficult to alcohol. Aqueous solutions with extended storage are hydrolysis.
On chemical structure and pharmacological properties similar to the complex difeniluksusnoy acid esters (spazmolitin etc.).
Amizil has diversified pharmacological activity, has a moderate stages, protivogistaminnoe, antiserotoninovoe, mestnoanesteziruyuschee effect.
Most expressed his holinoliticheskie properties; It blocks the central and peripheral holinoretseptory. Due to the strong influence of the central holinoreaktivnye system (mainly holinoreaktivnye m) amizil refer to the group of central holinolitikov.
Impact amizila expressed in the central nervous system of oppression convulsant and toxic substances holinomimeticheskih anticholinesterase and, in a calming effect, strengthening of barbiturates and hypnotics funds analgetikov, mestnoanesteziruyuschih funds. Amizil oppresses also kashlevoy reflex. It blocks the effects of nerve excitation wandering (big increases, decreases Secretion glands, decreases tone smooth muscles).
In neurological and psychiatric practice amizil in connection with its calming (tranquilizing) of the nominated : with Pichinde and neurotic reactions in patients with the syndrome alarming voltage; In light of anxiety and depression, neyrodermitah etc. You can assign amizil with Neuroleptics, other tranquilizers , barbiturates. In psychiatric practice in the light of new, more effective drugs amizil is limited.
As a central tool holinoliticheskoe amizil effective in Parkinson's disease and other disorders extrapiramidale. The drug can prevent or reduce the phenomenon parkinsonizma caused fenotiazinovymi derivatives, and butirofenonami rezerpinom. In an application with rezerpinom decline caused by the latest holinomimeticheskie effects.
In practice amizil anaesthetics can be used in preparing patients for narcosis and aftercare period. Appointment amizila with analgetikami heightens the effect of painkiller.
Like other cholinolytic amizil effective means to disease, accompanied by cramps smooth muscles of internal organs (stomach ulcer disease and gastrointestinal ulcer, cholecystitis, spastic colitis, etc.).
Amizil can assign patients suffering from coughing.
As midriaticheskoe amizil convenient tool for diagnostic purposes : it is strong, but missed a short extension.
For treatment of neuro-psychiatric diseases designate amizil inside (after eating) tablets to 0,001 - 0,002 grams (1 to 2 mg adults), 3 to 4 times a day. The course of treatment continues 4 to 6 weeks.
In practice anaesthetics as spasmolytic and antiphlogistic funds designated for 0,001 - 0,002 g of 1 - 2 - 3 times a day.
To enhance maybe give konyunktivalny bag drops 1 - 2 1 - 2% solution. Expansion is maybe 10-30 minutes; After 1, 3, 5-hour position is narrow.
Adverse events that can occur in recruitment amizila typically arise cholinolytic action. The drug can cause (like atropine), dry mouth, increased heart rate, increased pupil. In connection with mestnoanesteziruyuschimi properties can be observed showing language and sky admission drugs inside. Sometimes there euphoric and light dizziness. In large overdose may have motor and mental arousal, convulsions, gallyutsinatornye phenomenon (see Atropine).
The drug is contraindicated in glaucoma. Do not appoint him at the time and on the eve of drivers and other transport patients who require rapid mental and motor responses.
Method of issuance : white pill on 0,001 - 0,002 grams (1 to 2 mg) and powder (for the preparation of solutions).
Storage : List A. In a cool, dry place in the tightly closed container.
Solutions for Ophthalmic Practice producing distilled water. Prolonged storage solutions is not recommended, because at room temperature gradually hydrolysis products.
Rp. : T ab. Amizyli 0,001 N. 50
D.S. At one tablet three times a day.
R p. : Sol. Amizyli 2 ml 10%
D.S. On 1 - 2 drops in konyunktivalny bag (to increase pupil)
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