AMLODIPIN (Amlodipine).

     Etilovyy-5- 3-methyl esters (±) -2-[(aminoetoksi) - ethyl] -4 - (ortho-chlorophenyl) -1,4 - digidro-6- methyl-3, 5-piridindikarbonovoy acid.

     Available in a bezilata and maleate.

     Synonyms : Amlovas, Amlodis, Kalcec, Norvask, Normodipin, Stamlo, Amlovas, Normodipine, Norvasc, Stamlo.

     The white crystalline powder. Little is soluble in water sparingly in ethanol.

     On chemical structure has similarities with felodipinom (an atom in a molecule and groups COOC2H5 Cl).

     Amlodipina feature is a great time of the anti-hypertensive (up to 24 h), little to sinusny hub and atrioventrikulyarnuyu conductivity; Aggregation inhibits platelets.

     Absorbed slowly, but almost, bioavailability of 60-65% (due to the effect of "first pass" through the liver), C max, 6-12 h, T? - 35-48 h; out kidneys.

     Key testimony for the application : arterial hypertension, stable and vazospasticheskaya strokes.

     Due to the slow development impact and the length of the considered less dangerous and easier to use than products of this group of short steps.

     As published in the foreign literature indicates that in patients with hypertension hypertension amlodipina led to the use of reliable mortality, and in patients with IBS and ateroskleroticheskim stenosis of coronary arteries to reduce the frequency of cardiovascular complications without significantly changing risk deaths.

     Assign inside of 0,005-0,01 g (5-10 mg) one time a day.

     Side effects and contraindications are the same as those nifedipina.

     Amlodipin compatible with the products of major groups antigipertenzivnyh funds (diuretikami, ACE inhibitors and? - Adrenoblokatorami).

     Method of issuance : pills to 0.0025; 0.005 and 0.01 g (2,5; 5 and 10 mg) (N 20, 30, 100).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines