ANAPRILIN (Anaprilinum). (#) Izopropilamino-3- -1 - (1-naftoksi) -2-propanol hydrochloride.

     Synonyms : Inderal, Obzidan, Propranolol, Stobetin, Alindol, Angilol, Antarol, Avlocardyl, Bedranol, Betadren, Bricoran, Cardinol, Caridorol, Dederal, Deralin, Dociton, Elanol, Eliblok, Inderal, Inderex, Naprilin, Noloten, Obsidan, Opranol, Propanur, Propral, Propranolol hydrochloride, Pylapron, Sloprolol, Stobetin, Tenomal, Tiperal and others.

     The white crystalline powder. Mg in water and alcohol.

     Inderal is a b-adrenoblokatorom acting as a b-1, and 2-b adrenoretseptory (indiscriminate).

     By reducing the influence of the sympathetic impulsatsii b-adrenoretseptory heart Inderal reduces the frequency and force of heart, blocking positive effect inotropny chrono and catecholamines. It reduces the ability Oxytocics heart attacks and the amount of emission. Need attack oxygen is reduced.

     Blood pressure influenced anaprilina lowered. The bronchial tone of the blockade and 2-adrenoreceptor rising.

     The drug increased spontaneous and caused uterotonicheskimi means of reducing the uterus. Decreases bleeding during delivery and aftercare period.

     Inderal is rapidly absorbed by ingestion and relatively quickly flushed from the body. Peak plasma concentration is 1 to 1, 5 h after administration. The drug crosses the placental barrier.

     Inderal applied for the treatment of coronary heart disease, cardiac arrhythmia, as well as some forms of hypertension.

     When ischemia Inderal reduces the frequency of strokes, increases stamina to physical activity, limiting the need for nitroglycerin. The drug is effective in pain at rest, but particularly in strokes voltage. His use with resistance to other drugs, with the attendant departments, as well as hypertension. As antiaritmicheskoe means Inderal apply to sinusovoy and paroxysmal tachycardia, arrythmia, oils and predserdy fibrillation. The drug shows patients with ventricular zkstrasistoliey post-myocardial infarction.

     In sinusovoy tachycardia is usually a good rhythm, including in the case of resistance to the cardiac glycosides. The drug contributed to tahiaritmicheskoy form mertsatelnoy witness in the disappearance and bradiaritmicheskuyu interruptions and heartbeat.

     In hypertensive Inderal mostly in the early stages of the disease. Preparation is the most effective in patients younger (up to 40 years) with giperdinamicheskim type blood and the increased content of renin. Lower blood pressure by reducing emissions from the heart ischemia heart rate and reduce the impact of heart. Peripheral resistance to moderately high. The drug is Orthostatic Hypotension. There is evidence of the effectiveness of the drug also of renal hypertension.

     Anti-hypertensive effect anaprilina usilivvetsya combining it with gipotiazidom, rezerpinom, apressinom and other hypotensive drugs. - Adrenoblokatory, reducing renin secretion, activation weaken reninangiotenzinovoy system caused tiazidnymi diuretikami. [Under the title "bsilazin" issued abroad (Germannya) combination product containing 50 mg propranolol (Inderal, obzidan) in combination with 50 mg digidralazina (close to the structure and actions to apressinu).]

     While the application with hypertension (moderate and severe forms) anaprilina combined with a-adrenoblokatorom fentolaminom.

     It is also recommended to use anaprilina simpatiko- adrenalovyh crises in patients with dientsefalnym syndrome, as well as for preventing migraine attacks.

     Inderal urezhaet heart reduction and improves patients with thyrotoxicosis. He potentsiruet of tireostaticheskim and can be used to treat cardiovascular and neuropsychiatric disorders in patients diffuse toxic goiter. Patients who are tireotoksicheskim safe to be surgery and not perenosyaschih tireostaticheskie drugs, it is used for the pre-training.

     Assign Inderal inside (regardless of meal times). Usually starting in adults with a dose of 20 mg (0.02 g) 3 - 4 times a day. [There are receiving drug 3 - 4 times a day provides a more stable effect than dividing the daily dose of 2 admission. In effect, and lack of good endurance gradually increase the dose to 40-80 mg / day (with intervals 3 to 4 days ), up to a total dose of 320480 mg / day (in some cases up to 640 mg) with the appointment of the same dose in 3 to 4 admission.

     Normally, long-term use of Inderal (under close medical supervision).

     Termination of anaprilina (and other b-adrenoblokatorov) with coronary heart disease should be gradual. With the sudden cancellation drug may increase anginoznogo syndrome, and ischemic cardiac events, the deterioration of tolerance to physical activity, bronhiolospazm, changing rock properties of the blood (increase agregatsionnoy ability erythrocyte), and other side effects.

     Prolonged use of b-adrenoblokatorov in patients with coronary heart disease should be combined with the appointment of cardiac glycosides.

     In obstetric practice using Inderal for initiating and strengthening of labor activity in its primary weakness, and for the prevention of postnatal complications arising from violations of uterine cancer. Assign Inderal for delivery and the promotion of labor activity in the 20 mg dose of 4 to 6 times in 30 minutes intervals (80-120 mg / day). In the case of hypoxia fruit intake reduced. To prevent postnatal complications appointed to 20 mg three times a day for 3 to 5 days.

     In applying anaprilina possible side effects as nausea, vomiting, diarrhoea, aetiology, general weakness, dizziness; Sometimes allergic reactions (skin itch), bronhiolospazm. There phenomenon depression.

     In connection with the blockade and 2-adrenoreceptor may develop peripheral vascular syndrome Reynaud.

     The drug is contraindicated in patients sinusovoy aetiology, incomplete or complete atrioventrikulyarnoy blockade, as expressed by legal levozheludochkovoy heart failure, in bronchial asthma and a propensity to bronhiolospazmam, diabetes with ketoacidosis, pregnancy, a violation of peripheral arterial blood flow. It is undesirable to appoint Inderal with spastic colitis. Caution is needed, while the application of gipoglikemicheskih (risk hypoglycemia). For the diabetes treatment should be under the control of blood glucose.

     You can not take Inderal while Neuroleptics and tranquilizers. One must consider the possibility of oppression and speed reaction to the reception anaprilina (and other b-adrenablokatorov) operators, drivers and transport officials of similar professions.

     Patients who are feohromotsitomoy be given while anaprilinom a b-adrenolitiki (see Tropafen).

     With long-term use drugs to be especially careful to monitor the function of the cardiovascular system, the overall condition of the patient. Moderate aetiology arising out of the treatment is not evidence for the lifting of the drug, with a heavy dose reduces aetiology.

     In overdose anaprilina (and other b-adrenoblokatorov) and resistant aetiology injected (slowly) atropine solution (1 mg-2) and b-adrenostimulyator - izadrin (25 mg) or ortsiprenalin (0.5 mg).

     Product : pills to 0.01 g and 0.04 g (10 and 40 mg).

     Storage : List B. In the dark spot.

     An injection of anaprilina - 0.25% solution in ampoules and 1 ml (2, 5 mg in the ampoule). Cupping applied intravenously for cardiac arrhythmia and strokes. Usually 1 mg enter first, and then, depending on the effects of endurance and increase the dose 5 to 10 mg. Enter slowly.

     To reduce the inner pressure of open glaucoma using Inderal as eye drops. Abroad issued for the 1% solution called Tonum "(" To num "). Reducing inner pressure due mainly to reduced secretions watery mist. Also, the domestic product formulation.

Materials allowed to copy only with the active hyperlink to the handbook of medicines