ANTIPIRIN (Antipyrinum). Fenil 1--2 3-dimetilpirazolon-5.

     Synonyms : Analgesin, Anodynin, Azophen, Methozin, Parodyne, Phenazonum, Phenazone, Phenylon, Pyrazoline, Pyrodin, Sedatin and others.

     Clear crystals or a white crystalline powder odourless, slabogorkogo taste. Very easily soluble in water (1:1), easy-to alcohol. The solutions (pH 6, 7, 0, 5) 120 + sterilized in C for 20 min.

     Phenazone was one of the first synthetic analgetikov, pirazolona derivatives, which has applications in medicine (1884). To obtain other analgetikov they have enjoyed relatively rare. Widespread use it currently does not have. But he lost values and remained in the nomenclature of medicines.

     Like other derivatives pirazolona, has an Phenazone, cough and in one way or another anti-inflammatory. On analgeziruyuschey and analgesic activity of this group of drugs similar to the product of salicylic acid. Derivative pirazolona reduce capillary permeability and the development of inflammatory responses. This mechanism is not clear. The impact on the system pituitary-adrenal glands, these connections do not have.

     The most active anti-drug of the group of heavily-Phenylbutazone ingibiruet biosynthesis prostaglandines. He assigned to non-steroid anti-drug group.

     Phenazone to moderate analgesic, antipyretic and anti-inflammatory effect. If the application had been some local hemostatic effect.

     When applied Phenazone nevralgiih, diseases.

     Are the adults inside of 0.25 - 0.5 g; Children aged 6 to place 0,025 - 0,15 g per admission on the basis of age. Is 2 to 3 times a day.

     Higher doses for adults inside : single 1 g daily 3 g.

     As hemostatic means Phenazone sometimes use (10-20% solution) to soak napkins and tampons with bow and parenchymatous krovotecheniyah.

     In appointing antipirina should take into account the possibility of hypersensitivity to the drug patients with a fixed memory and urticaria; Perhaps oppression blood (see Amidopyrine).

     Method of issuance : powder and pills to 0.25 g.

     The use of child practice issued pills to 0.05; 0,075; 0.1 and 0.15 g.

     Storage : List B. The well ukuporennoy packaging keeps from the world.

     R p. : Tab. Antipyrini 0.25 N. 10

     D.S. At one pill 2 - 3 times a day

     Rp. : Sol. Antipyrini 10% 30 ml

     D.S. To soak in the new Guapi bleeding from the nose

     Pills <<Ankofen>> (Tabulettae <<Ancophenum>>).

     Ingredients : antipirina and fenatsetina to 0.25 g, sodium benzoate kofein- 0.05 g. Analgeziruyuschee analgesic and antipyretic funds. Assign to one pill 1 - 2 - 3 times a day.

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines