BEMEGRID (Bemegridum). 2 - Methyl ztilglutarimid or 2, 6-diokso-4- methyl ethyl pyridine.
Synonyms : Ahypnon, Bemegride, Etimid, Eukraton, Glutamisol, Malysol, Megibal, Megimide, Methertharmide, Mikedimide, Zentraleptin.
The white crystalline powder odourless, bitter taste. Malorastvorim in water (0.5%), it is difficult to alcohol.
Solutions (at izotonichesnom sodium chloride solution; P N 5, 0 - 6, 5) in sterile + 105-110 C for 30 min.
Chemically Bemegride to derivative 2, 6-dioksopiperidina.
Bemegride is an antagonist of sleeping pills : it reduces toxicity barbiturates, removes blood and respiratory depression caused by these substances. Analepticheskoe bemegrida not limited to the antagonism with barbiturates. The drug has a stimulating effect on the central nervous system and is effective in respiratory and circulatory oppression of different origins.
Applied Bemegride in acute barbiturate poisoning; To overcome respiratory arrest in anaesthesia barbiturates, tiobarbituratami and other drugs (ether, ftorotanom etc.); To stop narcosis barbiturates and tiobarbituratami and accelerate the awakening in anaesthesia, and in other cases, requiring analeptikov , including the withdrawal of heavy hypoxic conditions.
Enter Bemegride intravenous slowly in the form of 0.5% solution. In acute barbiturate poisoning, as well as for the withdrawal of barbiturovogo and combined (with the use of barbiturates and other drugs) narcosis impose 5 to 10 ml (adult); With little or no effect of repeat injections at intervals 2 to 3 minutes to restore reflexes advancing or full restoration of breath, normalize blood pressure and pulse. The total number of input depends on the severity of drug poisoning and the general condition of the patient. The emergence of convulsions limbs car sends a signal to stop the introduction of the drug.
Entering bemegrida children dose reduced in many times, how much weight a child below the average adult body weight.
Bemegrida injection can be combined with the introduction mezatona, caffeine and other cardiovascular funds.
Bemegride as analeptika give Vein 2 to 5 ml of 0.5% solution.
In applying bemegrida in cases of acute barbiturate poisoning while others are necessary in these cases : washing stomach (admission into barbiturates), intravenous glucose solution or isotonic sodium chloride solution, the use of appropriate antibiotics to prevent infection, etc.
When a drug overdose possible nausea, vomiting, muscle car, convulsions.
Bemegride contraindicated in psychomotor institute.
Product : 0.5% solution bemegrida in isotonic sodium chloride solution in ampoules and 10 ml (10 ml containing 0.05 g product).
Storage : List B.
Storage (especially at low temperatures) of the liquid crystals may fall bemegrida that when heating (up to + 50 C) plane.
Rp. : Sol. Bemegridi 0.5 ml 10%
D.t.d. N 10 in ampull.
S. For intravenous infusion
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