BENZOBARBITAL (Benzobarbital)

     Chemical name : 1-Benzoil-5- etil-5- fenilbarbiturovaya acid

     Description : The white crystalline powder bitter taste. Very little is soluble in water, it is difficult to alcohol.

     Pharmacology : The drugs act-protivosudorozhnoe, sleeping pills, sedative.

Enhance brake GAMKergicheskie influence in central nervous system, especially in the cheeks, upstream activating the brain stem structures formation of neuronal inserted. Lowering the nerve fibers membrane permeability to sodium ions reduces the spread of epiochaga counters. Rapidly absorbed from the intestines, is metabolized by phenobarbital (is thus prolekarstvom) and then oxidized mikrosomalnoy system tsitohroma P450. Nor is associated with plasma proteins. Creates high concentrations in the brain, liver and kidneys. Penetrates gistogematicheskie through barriers and breast milk. Effect develops through 20-60 minutes after solid reception. T1 / 2 is 3-4 days. Excreted kidneys as unchanged, and in the form of metabolites.

     Application : Various forms of epilepsy, hyperbilirubinemia, Hemolytic disease of newborns, insomnia.

     Contraindications : Giperchuvstvitelnost, porphyria, anemia, bronchial asthma, respiratory failure, impairment of the function of liver and kidneys, diabetes, Ray, nadpochechnikovaya deficiency, diabetes mellitus, giperkinezy, depressive state (with suicidal attempts).

     Restrictions : To Gipotoniya, pregnancy, breast-feeding.

     Side Effects : Privykanie, drug dependency, lifting syndrome, disruption of the liver and kidney, respiratory depression, bronchospasm, hypotension, thrombocytopenia, anemia, throm, headache, dizziness, weakness, depression, refers, giporefleksiya, allergic reactions.

     Networking : enhance the effect of analgesics, anesthetics, gipnotikov, of narcosis, Neuroleptics, tranquilizers, tricyclic antidepressants, alcohol reduces - paracetamol, anti, tetracycline, grizeofulvina, glucocorticoids, mineralokortikoidov, cardiac glycosides, quinidine, vitamin D, ksantinov.

     Dosing and Administration : inside. Adult-to 0,1-0,2 g 3 times daily after meals. The highest single dose - 0.3 grams, the highest daily dose of 1 g.

Children : 3-6 years, 25-50 mg per reception (100-150 mg / day), 7-10 years 50-100 mg per reception (150-300 mg / day), 11-14 years - 100 mg at the reception (300-400 mg / day). The highest single dose 150 mg, the highest daily dose of 450 mg.

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