BENZONAL (Benzonalum). 1-Benzoil-5- etil-5- fenilbarbiturovaya acid.

     Synonyms : Benzobarbitalum, Benzobarbital.

     The white crystalline powder bitter taste. Very little is soluble in water, it is difficult to alcohol.

     Benzonal received as a result of <modification> molecule phenobarbital. As can be seen from the formula, it is different from phenobarbital, but it is in the position N 1 contains benzoic acid balance.

     Like phenobarbital, benzonal has protivosudorozhnoy (protivoepilepticheskoy) activity, but has a less pronounced effect gipnosedativny.

     Pharmacokinetic studies revealed that benzonal rapidly metabolised in the body, releasing phenobarbital, which has protivosudorozhny effect. Benzonal may therefore be seen as <prolekarstvo>.

     Benzonal applied for the treatment of convulsions forms of epilepsy different origins, including cases and dzheksonovskimi focal seizures.

     Combined with geksamidinom, carbamazepine, difeninom protivoepilepticheskimi and other drugs used to treat benzonal bessudorozhnyh and polymorphic fits.

     Assign inside a pill (after eating).

     Under the dose for adults is 0.1 - 0.15 - 0.2 grams daily to 0.8 g; More appoint 0.1 g three times a day.

     Higher doses for adults : single 0.3 g daily 1 year

     Children aged 3 to 6 years appoint 0,025 - 0,05 g per reception (0.1 - 0.15 g / day), 7 - 10 years - to 0.05-0.1 g per reception (0 5 - 0.3 g / day), 11-14 years - 0.1 g per reception (0.3 - 0.4 g / day).

     Higher doses for children (age) : single 0.15 grams daily 0.45 g.

     Treatment starts with a single receiving a single dose. After 2 to 3 days gradually increased until an optimal daily intake (reducing the frequency and intensity and termination fits with good endurance). If the patient had previously convulsants other means, the treatment benzonalom must move gradually; Benzonalom replace first one and then (after 3 to 5 days), the second and third doses of the old drug. Once fully replace former drug dose benzonala gradually increased until the end of dwarfism or reduce their frequency and severity of the intensive. Treatment continued long-term (at least 1 - 2 years), even in the absence of dwarfism. When resistant compensation dose slowly reduced to a single dose a day, continuing, but a long reception of the drug. In the case of smaller doses of dwarfism should revert to the old daily intake.

     Like phenobarbital benzonal is "inducer" enzymes increased activity monooksigenaznoy liver enzyme system and therefore can be used to treat giperbilirubinemy. There is evidence of the effectiveness of adjuvant therapy benzonala hemolytic disease of the newborn and better endurance than phenobarbital.

     Benzonal usually well. In convulsants dose is expressed mood, mental sluggishness, sunk, headache. These phenomena (as well as ataxy, eye, speech difficulties), there are only a few cases, with high sensitivity, or overdose, and then requires a reduction in dose or the appointment of caffeine (0.05 - 0.075 g per reception). Some patients deteriorating appetite.

     For patients who had previously barbiturates, when the treatment can disrupt sleep benzonalom that easily eliminated overnight destination 0.05-0.1 grams of phenobarbital or other means sleeping pills.

     Benzonal contraindications to liver and kidney damage in violation of their duties in the cardiac decompensation.

     Product : 0.1 grams of pills in a package of 50 pieces, and 0.05 g (for children) in a package for PC cards.

     Storage : List B. The well ukuporennoy packaging keeps from the world.

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