Beroksan (beroxanum)

	Beroksan (beroxanum) BEROKSAN (Beroxanum). The preparation containing a mixture of two-furokumarinov ksantotoksina and bergaptena available from planting fruit plants Pasternak (Ra stinaca sativ and L.), herewith. umbrella, seldereynyh Umbelliferae, or Ar-ia seae. Chemically ksantotoksin an 8-metoksi 6-, 7 - or 8-furokumarinom metoksipsoralenom and bergapten metoksi-5 - 6 - 7-furokumarinom. The white with a yellowish sheen crystalline powder and odourless. Almost nerastvorim in the water, little is soluble in alcohol, easy-to chloroform. Ksantotoksin published abroad under the title : Puvalen, Ammoidin, Meladinine, Meloxine, Methoxsalen, Methoxypsoralen, Methoxysalen, Metoxin, Oxsoralen, Puvalen, Xanthioxin and others. Application beroksana in medical practice based on the properties of different furokumarinov (ksantotoksina etc.) sensibilizirovat skin of the world and to encourage the formation of melanocarcinoma endogenous skin pigment (derivative triptofana) melanin, the irradiation of ultraviolet light. Those properties have other preparations containing furokumariny. In the application, together with ultraviolet obluchenism these drugs can help restore skin pigmentation with vitiligo. In Depigmentation skin (leykodermii) of melanocarcinoma destruction, the effect is observed. In some cases, furokumariny effective in gnezdnoy alopetsii (circular). It is an effective method of treating skin diseases : psoriasis, mushroom mycosis, vitiligo, etc. - is fotohimioterapiya. In this method, fotosensibiliziruyuschie drugs combined with radiation wavelength ultraviolet light (320-390 nm). As fotosensibilizatora applied furokumariny (beroksan, psoralen, etc.), the most effective of them 8-metoksipsoralen (8 - MOP), a ksantotoksin, published abroad under the name "Puvalen (R uvalen). In applying the method fotohimioterapii (PUVA- therapy), 8 - MOP designate inside only a day of exposure for 2 h before the session. Dose of drug depends on the patient's body mass; From 2 to 4 tablets (15 mg) in body weight from 50 to 90 kg. Beroksan (of the content therein only part ksantotoksina) are second-best 8 - MOP in fotohimioterapii method of long ultraviolet rays. There is evidence of the effectiveness of a combination of long fotohimioterapii UV radiation on the outside of furokumarinov; In areas affected adversely solutions 8 - MOP, beroksina (0.5%) or psoralena (0.1%). Beroksan appointed to vitiligo and gnezdnoy alopetsii inwards in the form of tablets and External a solution to the prolonged. Inside appoint 0.02 g (1 tablet) for admission; Take the morning of 1 to 4 times (depending on individual sensitivity and season the year) to 1 pill for 4 - 3 - 2 and 1 h before irradiation. The course will consist of 4 to 6 cycles intermittently between 15 to 20 days. Total dose for a course of treatment for adults 250-300 pill. For children over 5 years dose is reduced by 1 / 3 to 1 / 2 depending on age. In addition to receiving the drug inside, rubbing solution in the pockets of defeat and the subsequent obluchayut their ultraviolet light. Rubbing first in the 12 and 8 h before irradiation (night), then in subsequent cycles, 4 - 2, and 1 h before irradiation. In pockets of vitiligo or gnezdnoy alopetsii evenly rubbing finger in a rubber glove or finger-stall 0.5% solution beroksana previously caused in the pockets of pipettes. Do not eat these pockets of water to the radiation. Upon discovery of the extreme sensitivity of the skin to 0.5% solution beroksana raise its 70% alcohol to 1:3; 1:4, etc. Only during one cycle to produce 10-20 tumbled and exposure. Mercury exposure mode patient quartz lamp set on the basis of preliminary data erythemic. In the absence of the necessary effect, a treatment repeated at 1, 5, 2 months. During the summer months, in order to avoid the sum of the artificial and natural UV radiation, it is recommended to combine the use beroksana dosed with sunlight exposure. �� , �� , � �� . Treatment must be carried out under the close supervision of a doctor. �� : �� , ��, �� , ��. Side-effects are reduced or are at lower doses, or a temporary interruption of treatment. Patients must warn of the possibility of bulleznyh dermatitis when combined exposure pockets defeat Mercury quartz lamp and the effects of solar radiation. It should strictly observe the prescribed radiation treatment. �� . Contraindications to individual intolerances, diarrhoeal diseases, hepatitis, liver cirrhosis, acute and chronic nephritis, diabetes, cachexia, hypertension expressed endocrinopathy, tuberculosis, diseases of the blood, heart, central nervous system, malignant and benign tumors, pregnancy. �� 5 �� 60 ��. Method of production : tablets of 0.02 grams in a package of 50 pieces; 0.25% and 0.5% solutions in orange glass bottles for 50 ml. Storage : List B. In a dry, cool, the dark spot. Puvalen issued tablets to 0,015 g (15 mg).
Materials allowed to copy only with the active hyperlink to the handbook of medicines