BLEOMITSETINA HYDROCHLORIDE (Bleomycetini hydrochloridum).

     Bleomitsetin - antitumor antibiotic produtsiruemy Streptoverti with illium griseocarneum var. bleomycini.

     He is one of the drugs group bleomitsina (bleomycin A 5).

     As the operation is similar to bleomitsinom.

     The white or yellowish white amorphous powder, readily soluble (hydrochloride) in the water.

     It'sa force tumor origin. Suppress DNA synthesis. No injures blood. There has immunosuppressive properties.

     Applied in adults with disseminated malignant tumours : in the mucous membrane of squamous cancer of the oral cavity, language, mindalin, larynx; Squamous skin cancer, cervix and vulva; If chlamydia, teratoblastomah testis and penis cancer I-II stage (in combination with vinblastinom) . Intraoral introduction recommended pleurisy and astsitah in patients with ovarian, breast, lung cancer.

     Enter intravenously or intramuscularly. Using different modes of : a) 15 mg (9 mg / m 2) 3 times a week for 4 to 5 weeks; B) to 30 mg 2 times a week for four weeks; C) to 30 mg daily during the 5 to 6 days.

     Once the therapeutic effect to repeat courses at intervals of 3 to 4 weeks for the regime.

     In cavity impose 50-60 mg (after evacuation from a liquid).

     The contents of a bottle of hydrochloride bleomitsetina dissolve in the intramuscular a 3 - 5 ml, with intravenous-20 ml, with intraoral-40 ml isotonic sodium chloride solution; Dissolve just before the introduction.

     In applying the drug may increase body temperature, diskeratoz, allergic reactions, disease, pneumonia. In the process of treatment should be carefully monitor the condition of patients. If necessary, designate an appropriate therapy or cease the use of the drug.

     Contraindications : grave breaches of kidney function, chronic pneumonia, pulmonary and cardiac failure, allergies, radiation, thrombocytopenia.

     Patients older than 70 years should not be imposed on the treatment of more than 200 mg / m 2.

     Product : bleomitsetina hydrochloride for injection (V leomycetini hydrochloridum pro injectionibus) to 0,005 grams (5 mg per base bleomitsetina) in ampoules or bottles with a capacity of 5 ml.

     Storage : List A. In the dark place at a temperature no higher than  +10 C.

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