BLEOMITSIN (Bleomycinum).

     Antitumor antibiotic product life fungus Str. verti with illus. Water polypeptide.

     Synonyms : Blanoxan, Blenoxane, Bleocin, Bleocamicina.

     Bleomycin is a group of closely related structures of natural compounds with anticancer activity (bleomycin A2, B2, etc.). The mechanism of cytotoxic action on the ability to cause DNA fragmentation. Bleomycin has the ability to accumulate (with a parenteral) in the skin, and therefore it is particularly effective for skin cancer, as well as the mucous membranes. It oppresses kostnomozgovoe relatively little blood. Do not have a significant impact immune.

     Applied primarily squamous cancer mucous membranes of the oral cavity, mucus, larynx, oesophagus, and penis cancer, teratoblastome testis and ovary and chlamydia.

     The drug is more effective in the early stages. In metastases of malignant tumors therapeutic effect is not observed. In oesophagus cancer is recommended in combination with radiation therapy, with teratoblastome - vinblastinom in combination with other therapy or medications.

     Enter intravenously or intramuscularly. For intravenous drug injections to throw in 20 ml isotonic sodium chloride solution, introducing slowly (no faster than 5 min). For intramuscular injections grow in the 5 to 10 ml isotonic sodium chloride solution; When the pain is tentatively set 1 - 1 - 2 mL of 2% solution novocaine.

     Enter adults usually dose of 15 mg (0,015 grams) a day or 30 mg 2 times a week. Heading dose should not exceed 5 to 6 mg / kg (usually 300 mg). Repeated courses to be conducted with care, reducing the time and dose rate. The interval between courses 1, 5, 2 months. Sometimes appoint supporting drug dose 15 mg 1 every 7 - 10 days.

     Persons age drug impose a lesser dose (15 mg, 2 times a week). Children should appoint a drug with caution, reducing the dose according to weight.

     In applying bleomitsina could experience different side effects. In a day, sometimes rising body temperature, may nausea, vomiting, anorexia, stomatitis, conjunctivitis, vulvit, Alopecia. Frequently there are changes in the skin : focal ALVIMARINE, hyperpigmentation and dermatitis. There may also observed hyperesthesia distal phalanx (drop), Blush from the fingertips, fractures nails. Typically, these events developed by the end of the course of treatment, are the dobrokachestvenno and does not require termination of treatment. Remote byproduct could be pneumonia. In bleomitsinom treatment and after 3 to 4 weeks after treatment, it is necessary to study X-ray chest. If caught in the treatment of pneumonia, treatment ceased.

     For injection using freshly solutions. Trapped solutions under the skin is not allowed.

     Product : in ampoules of 0,015 g (15 mg) of injectable applications with the solvent (20 ml isotonic sodium chloride solution).

     Storage : List A.

Materials allowed to copy only with the active hyperlink to the handbook of medicines