Budesonid (budesonidum)
BUDESONID (Budesonidum).
Synonyms : Apulein, Benakort, Budezonid, Budenofalk, Gorakort, Pulmikort, Rinokort, Tsikortid Tsiklokaps, Apulein, Budenofalk, Budesonide, Cycortid Cyclocaps, Goracort, Pulmicort, Rhinocort.
White or not a white powder. Almost nerastvorim water and heptane, sparingly soluble in ethanol, a well - in chloroform.
Glyukokortikosteroidny drug similar in structure to triamtsinolona atsetonidu but different in the absence of molecular fluorine atom (and the replacement of methyl radicals in atsetonidnoy group of hydrogen and propyl).
In connection with the small BAS has expressed no systemic action, and moved better than fluorinated drugs is significant atroficheskih skin in long-term use.
In inhalation in the alveolus fell about 25% of dose, C max of 15-45 min, T? - 2.8 h; displayed mostly kidneys.
Применяют в основном местно: в виде мази (крема) - при атопическом дерматите, псориазе, экземе и в виде ингаляций - при бронхиальной астме и обструктивном бронхите. At a reception inside the capsules (Budenofalk) offered (as an anti-vehicle) with the disease Krona.
Inhalation adults initially appointed (with aggravation of asthma) to 0,2-1,6 mg a day (a few receptions), in less severe cases, 0,2-0,8 mg / day; Children older than 7 years - 0,2-0,8 mg daily in the reception 2-4). После ингаляции тщательно прополоскать горло.
Ointments cause for the affected areas of skin first two times and then one time a day.
Inside appointed as capsules (not liquid before eating) to 0,003 grams (3 mg) three times a day.
Possible side effects : when the local application-bleeding, skin atrophy, dermatitis, tinea, hyperpigmentation, a sense of burning, itching of the skin; In inhalation - disfoniya, cough, sore throat pain.
Препарат противопоказан при беременности и кормлении грудью; для ингаляций - при туберкулезе, грибковой инфекции органов дыхания; для местного применения - при инфекциях кожи, обыкновенном лишае; для введения внутрь - при инфекциях ЖКТ, тяжелых нарушениях функций печени.
Method of issuance : powder for inhalation (0.1 and 0.2 mg / dose; Doses of 100 and 200), complete with asthma (cyclo or turbuhalerom) and capsules (0.2 mg / dose; 100 and 200 doses); 0,0125%; 0,025% и 0,05% суспензия для ингаляций в контейнерах по 2 мл (N. 4, 20); дозируемый аэрозоль для ингаляций в баллончиках по 10 мл (0,05 мг/доза - Будесонид-мите , and 0.2 mg / dose-Budesonid- forte; 200 doses); 0.025% ointment and cream in tubes of 15 grams; capsules of 0,003 grams (3 mg) (N. 10, 50).
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