CALCIUM FOLINAT (Calcii folinas; Calcium-folinate).

     Kaltsievaya salt folinovoy acid or 5-formil-5, 6, 7, 8-tetragidrofolievoy acid, ie 4'- (N-[(2-Amino - formil 5, 6, 7, 8-tetrahydro -4-acid pteridil) methyl]) aminobenzoil -L- glutaminovoy acid.

     Issued in a pentahydrate.

     Synonyms folinovoy acid: Leykovorin, Tsitrovorum- factor (name because folinovaya acid is a growth factor bacteria Leuconostoc citrovorum) Chemifolin, Lederfoline, Rescufolin, Tonofolin and others.

     Yellow-white crystalline powder. Easy soluble in water. Fragile to light.

     According to the chemical structure and physiological activity close to folic acid.

     Folinovaya acid is a product of making folic acid (see) in the body and plays a role in its active metabolite. Making folic acid folinovuyu happening with ascorbic acid.

     Folinovaya acid, and folic, effective with megaloblasticheskoy and anaemia, disease, but the benefits of folic acid is not. The main medicinal value folinovoy acid is its antidotnom action against the drug (mainly Vaccination) means a folic acid antagonists. For this purpose, its use as kaltsievoy salt.

     Main application folinat calcium antagonist is a side of the antitumor drug metotreksata (see).

     Vaccination of metotreksata (growth inhibition actively proliferating tissues delay growth of malignant tissue) associated with inhibition and blocking digidrofolatreduktazy tetragidrofolata education needed for DNA biosynthesis. Along with antitumor effect occurs, however, oppression blood. Calcium helps to restore folinat folate metabolism, prevent damage to bone marrow cells, protects disorders and allows Methotrexate necessary for tumor high-dose chemotherapy.

     Calcium can be used as folinat metotreksata Antidote to prevent possible toxic to the elevated, high and excessive doses, and developed from conventional doses metotreksata toxic manifestations (Necrotic lesions disease, enteropatii etc.).

     Apply calcium folinat struyno intramuscularly or intravenously. Before using drugs dissolve in 1 - 2 ml isotonic sodium chloride solution. The solution is suitable for use in over 12 h at his store in a cool place (not more than eight C).

     In therapy metotreksatom in high doses (1-5 g), calcium folinat give occasional dose of 3 to 10 mg / m 2, at high doses metotreksata (10 to 20 g), in an intake of 10 to 20 mg / m 2. Started injections through June 18, but no later than 24 hours after acute metotreksata, then the 6-hour intervals for a period of 48-72 hours Total treatment-10 - 12 dose (of Z0 to 360 mg).

     For kupirovaniya expressed toxic reactions of metotreksata (vomiting, increased temperature, etc.) should enter folinata intravenous calcium solution, it should be an increase in the dose of 2 - 3 times, and the interval between the introduction antidote reduced to 3 hours.

     If development toxic phenomena using conventional doses of calcium metotreksata folinat recommended dose of 5 to 10 mg / m 2 3-hour intervals until the disappearance of toxicity.

     Calcium folinat contraindications when patients anemia and other scarce V12- anemia.

     Using the drug in high doses can be seen allergic reactions.

     Form release: in 3 ml ampoule capacity; Containing of 0.00324 grams (3, 24 mg) or 0.0324 g (32, 4 mg) folinata sufficient calcium (Ca lcii folinas lyophilisatum pro injectionibus), in a package of five vials with Annex 5 vials with 2 ml isotonic sodium chloride solution for injection.

     Dried product is a porous mass of light yellow (for the smaller dosage) to yellow (for a large dosage) colors.

     Storage: List B. In sheltered from the world scene with a temperature of not more than 25 'C.

     Abroad folinat calcium (Ca lciumfolinat- bewe E) appears as the solution in the ampoule containing at 0,003 g (3 mg), 1 ml; 30 mg of 3 ml and 100 mg in 10 mL and capsules for 0,015 grams (15 mg). Large doses are intended for use in combination with 5-ftoruratsilom to treat tumors, particularly cancer rectum. In our country still do not have enough data on that subject.

     Leykovorin- calcium (L e ucovorin Sa), and other drugs calcium folinata produced in different dosage.

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