CALCIUM PANTOTENAT (Calcii pantothenas).

     CALCIUM salt D (+) pantotenovoy acid.

     Synonyms : Calcipan, Calcium pantothenicum, Calpanate, Cutivitol, Pancal, Panthoject, Pantholin, Pantotene, Pantothaxin, Pantotone, Pentavitol.

     White melkokristallichesky powder. The easily soluble in water, very little of alcohol. Weak gigroskopichen. Aqueous solutions (pH 6, 5 -9 0) optically active; Specific rotation (25) - (+28'); Sterile with 100 'C for 30 min.

     Pantothenic acid (from the Greek word "pantoten" everywhere, everywhere. Pantothenic acid is designated as one of the authors of "vitamin C 5, others as vitamin Vz.) [D (+), a g-dioksi- b, b - dimetilbutiril- b-Alanine] is widespread in nature. Most rich food sources are its liver, kidney, egg yolk, fish roe, peas, yeast.

     Inside the Pantothenic acid is a member of the kofermenta A, which plays an important role in the acetylation and oxidation. Pantothenic acid involved in the Carbohydrate and Fat exchange and in the synthesis of acetylcholine. It contains significant amounts in Kore adrenal corticosteroid and promotes education.

     Requirements in pantotenovoy acid is 10 to 12 mg per day. When heavy physical labour and the lactating women, it increased to 20 mg. In humans Pantothenic acid is generated in large quantities coliform bacilli, and beriberi resulting from the absence of pantotenovoy acid, a person is not there. Different animals when there are insufficient pathological processes such as beriberi.

     As drug use limestone salt pantotenovoy acid (obtained by synthetic) in various pathological conditions involving violations of metabolism; When polinevritah, neuralgias, paresteziyah, eczema, allergies (dermatitis, hay fever, etc.) and trophic ulcers, burns, toxaemia of pregnancy, chronic liver diseases and chronic pancreatitis, gastrointestinal tract diseases life expectancies for Nature (gastroduodenit etc.).

     Improving energy of uterine function attacks and increasing kardiotonichesky effects of cardiac glycosides, pantotenat calcium increases their therapeutic effectiveness.

     In surgical practice used to remove calcium pantotenat atony bowel after an operation for gastroenteric tract.

     Assign to reduce toxic streptomycin and other anti-tuberculosis drugs.

     Recently, they used calcium pantotenat in adjuvant therapy in patients with GHB alcohol syndrome.

     Enter calcium pantotenat inside, intramuscularly or intravenously.

     Inside designate an adult to 0.1 - 0.2 g 2 - 4 times a day; Children 1 to 3 years in the 0,005-0.1 g per reception, from 3 to 14 years - 0,1-0 , 2 g accepting two times a day. Daily intake for adults 0.4 - 0.8 g, for children 0,1 - 0,4 g.

     In DERMA practice used in high doses : adults and 1, 5 grams a day, the children of 0.1 - 0.3 g 2 - 3 times a day.

     When postoperative bowel atony appoint adults to 0.3 grams every six hours

     The course of treatment is continuing, depending on the nature of the disease to 2 months.

     Parenteral introduce adults to 0.2 - 0.4 g (2 - 4 ml 10% solution or 1 - 2 mL 20% solution) 1 to 2 times a day for children up to 3 years old are in a single dose of 0,05-0 1 g (0.5 to 1 ml 10% solution), from 3 to 14 years - to 0.1 - 0.2 g (1 - 2 mL 10% solution) 1 to 2 times a day.

     In order to correct the side effects of anti-tuberculosis drugs tablets and solutions nominated for the entire course of treatment.

     When opioid syndrome drug designate intravenously or intramuscularly (depending on the severity of the state) to 0.5 grams a day (5 ml 10% solution), and alcohol-delirii 1 g (10 mL 10% solution) for 10 days.

     Sometimes calcium pantotenat apply to the local tools with burns, slowly healing wounds. Assign a 5% solution of 2 to 3 times a day.

     With diseases of the upper respiratory tract and bronchial used in aerosol form : using 4% solution (0.2 g, 5 ml of water), who inhale 10 - 15 minutes each day during the 7 to 8 days.

     Pantotenat calcium usually well. When ingestion possible nausea, heartburn, vomiting; Intramuscular injections in pain and in isolated cases, of the infiltration.

     Method of issuance : pills to 0.1 g; 10% solution in ampoules of 2 and 5 ml and 20% solution in 2 ml ampoules.

     Storage : pills, in a dry, the dark places; Capsules-in the dark place at a temperature of not more than 30 'S.

     Rp. : Ta b. In alcii's ntothenatis 0.1

     N. 50

     D.S. At one tablet three times a day (adult)

     R p. : Sol. Sa lcii antoth r e n tis a 2 ml 10%

     D.t.d. N. in ampull 10.

     S. On 1 - 2 1 ml intramuscularly once a day (children 10 years old)

     R p. : Sol. Sa lcii p antothen tis 10% and 5 ml

     D.t.d. N. 10 in a mpull.

     S. At 5 ml intramuscularly (with opioid syndrome)

     Calcium pantotenat part of the combined multivitamin preparations (see Undevit, Gendevit, Kvadevit, Glutamevit, Komplivit).

     See also Pantogam.

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