KAPREOMITSIN (Capreomycin).

     Synonym : Kapastat, Capastat.

     Polipeptidny complex, isolated from Streptomyces capreolus (mixture kapreomitsina IB and small quantities kapreomitsina IIA and IIB). Rasvtorim water.

     Has the electoral activity of Mycobacteria tuberculosis.

     When ingestion poorly absorbed in the digestive tract; With the introduction of intramuscular C max of 1-2 h, T? 3-6 hrs; not being biotransformation, provides kidney.

     Refers to stand tuberculosis drugs.

     Assign (in combination with other anti-TB drugs) (deep) intramuscularly or intravenously at 15-16 mg / kg (2 ml 0.9% solution of sodium chloride) per day (1 g) over 2-3 months.

     A cross-resistance to kanamycin, amikacin, but not to streptomycin.

     Provides ability, and nefro- gepatotoksicheskoe effect; It is also possible to neuralgia, nerve-muscle violation conductivity, radiation or leucocytosis, gipokaliemiya, gipokaltsiemiya, gipomagniemiya, allergic reactions; At introduction, infiltrates, sterile abscesses, pain.

     In the experiment has teratogenic effects.

     The drug is contraindicated in pregnancy, breast-feeding, infant.

     Product : dried powder for injection solutions in bottles for 1 year

     Storage : List B.

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