KAPTOPRIL (Captopril). 1-[(2S) -3 - Merkapto-2- metilpropionil] L - proline.

     Synonyms : Kapoten, Tenziomin, Acepril, Aceten, Alopresin, Capoten, Capril, Captolane, Captoril, Catopil, Lopirin, Properil, Tensiomin, Tensoprel and others.

     Captopril is the first synthetic inhibitor of the angiotensin converting enzyme used in medical practice. So far, it is the main representative of this group of drugs.

     Assign Captopril to treat hypertension and congestive heart failure.

     As a means of antihypertensive use in various forms of hypertension, including in cases resistant to other antihypertensive drugs, with renovaskulyarnoy hypertension.

     There are performance Captopril with hypertension in patients with chronic nephritis. However, it must be borne in mind that the application of the drug may develop proteinurii and nefrozopodobnogo syndrome.

     Captopril is effective in congestive heart failure, including cases resistant to other medicines (diuretikam, cardiac glycosides, etc.), in combination with cardiac nedostatochiosti arterial hypertension, congestive heart failure in patients with IBS, bronhospasticheskih state.

     Captopril raise the peripheral (mainly resistant) vessels, reducing AD, reducing pre - and postnagruzki to attack and heart failure, improve blood circulation in a small circle and respiratory function, lower renal vascular resistance, and improve blood circulation in the kidneys.

     There are data on the strengthening of Captopril antianginalnogo Nitrosorbid; To appoint Captopril with nitrates in the resistance to the latter and to reduce the development of tolerance.

     Assign Captopril inside. Therapeutic doses for adults of 37, 5 to 150 mg / day (12, 5 to 50 mg three times daily); For children, the rate of 1 to 2 mg / kg per day.

     The length of treatment depends on the course of the disease, the effectiveness and acceptability of the drug (20, 30 or more days).

     In PNDS crises may sublingvalnoe use (25 mg).

     When selecting dose Captopril is usually well. In high doses, can greatly decrease AD. There tachycardia, headache, loss of appetite, a violation of taste sensations, allergic skin reactions, neutropenia. In addition, there may be a proteinuriya and nefrozopodobny syndrome.

     Contraindications : pregnancy, breast-feeding, and leyko- trombopeniya.

     Product : pills to 25; 50 or 100 mg in a package of 20 to 30 pieces.

     Storage : List B. In the dark spot.

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