KARBAHOLIN (Carbacholinum).

     N - (~) - Karbamoiloksietil) - trimethylammonium chloride.

     Synonyms : Carbacholum, Carbachol, Carbaminoylcholine, Carbamiotin, Carcholin, Doryl, Duracholine, Enterotonin, Glaucomil, Jestril, Lentin, Moryl, Tonocholin and others.

     The white crystalline powder with low odor aliphatic amines. Gigroskopichen. Very easily soluble in water, it is difficult to alcohol, almost nerastvorim broadcast and chloroform. The solutions (pH 5, 0, 7, 0) + 100 sterilized with C for 30 min.

     On chemical structure and pharmacological properties similar to acetylcholine; More active and has a longer-lasting effect, since no hydrogen cholinesterase.

     Resistance to drug use them not only for injecting, but for the reception inside. In oral and parenteral drug use is rapidly absorbed.

     Karbaholin zffektivno (more than acetylcholine) increases the tone muscles bladder and bowel. When local application (in the form of eye drops) reduces the inner pressure in glaucoma.

     Dose for adults when administered 0,0005 - 0,001 grams (0.5 to 1 mg), and subcutaneously, intramuscularly at 0.0001 0.00025 grams (0.1 - 0.25 mg) 2 - 3 times day. When intravenously (0.00005 mg g = 0.05) to be very careful : introducing drug slowly. These doses due to the high activity of the drug should not be exceeded.

     Higher doses for adults : single-into 0,001 grams, under the skin 0.0005 g; Daily-into 0,003 grams, under the skin 0,001 g.

     When glaucoma solutions karbaholina (0.5 to 1%), fluid in the bag konyunktivalny 2 to 6 times a day. Karbaholina concentration and frequency backfilling be collected individually for each patient, as well as in connection with a very limited and maybe muscle spasm tsiliarnoy possible headache and pain in the eyes.

     Contraindications, possible complications and assistance measures are the same as for acetylcholine. Before karbaholina sometimes feeling heat, salivation, nausea, aetiology; These phenomena are smaller doses.

     Product : powder.

     Earlier karbaholin issued in the form of powder and finished dosage forms : tablets to 0,001 g and 0.01% and 0.025% solutions of 1 ml ampoules.

     Recently finished dosage forms are excluded from the range of medicines. They proposed instead to use atseklidinom (see).

     Since powder karbaholina not deleted from the range, possibly as appropriate use division to make ex tempore, including eye drops.

     Abroad, issued eye drops karbaholina (Carbacel, Isopto carbachol, etc.) in the form of 0.75%; 1, 5%; 2, 25% and 3% solutions. To narrow missed during surgical eye operations produced 0.01% solution (Miostat intraocular). Enter 0.5 ml of cell perednnyuyu eyes.

     Storage powder karbaholina : A. In a list ukuporennoy packaging keeps out of the light, dry place.

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