KAVINTON (Cavinton) *.

     Ethyl ether apovinkaminovoy acid.

     Synonyms : Vinpocetine, Vinpocetine, Vinpocetinum, Inex.

     The white crystalline powder, almost nerastoorim in water, soluble in alcohol.

     Reverse (Vinpocetine) is a semisynthetic derivative devinkana alkaloid contained in the plant periwinkle (Vinica and Vinca minor L. e recta Rgl. E t S hmalth); Please. kutrovyh (n Arosu a eae c).

     Previously, it was found that extracts from Madagascar have salts and anti-hypertensive effect, have some sedative effect. Isolated from Madagascar pygmy vinkamin (vinkaminovoy acid methyl ester) was proposed to be applied (under the title "Devinkan, Minorin" vincan e-D, M inorin) as sosudorasshiryayuschego funds. As a result, clinical research, it was found that devinkan particularly effective in violation of cerebral circulation, and subsequently reverse a product which has received international name "Vinpocetine.

     Reverse brain vessels increases, increases blood flow, improves the supply of oxygen to the brain and helps glucose utilization. Ingibiruya fosfodiesterazu, preparation leads to nakoplennyu tsAMF in tissues; The aggregation of platelets decreases. There is only a small reduction in AD Systems.

     Salts of kavintona to direct Bath impact on smooth muscle. The drug increases metabolism noradrenalina and serotonin in the brain tissue, reduces pathologically elevated blood viscosity facilitates erythrocyte deformability.

     Applied with neurological and psychiatric violations of the cerebral circulation disorders (post-stroke, post, ateroskleroticheskogo origin); In memory disorders, golovokruzhenii, bruising, etc.; In hypertensive encephalopathy, vazovegetativnyh symptoms of the menopause and others.

     In ophthalmic practice in reverse designate ateroskleroticheskih and angiospasticheskih changes and vascular netted skins, degenerative changes of yellow spots, secondary glaucoma associated with partial brain vessels, and others.

     Also effective in reducing vascular hearing or toxic origin (medically) and golovokruzhenii labirintnogo origin.

     Is the interior in the form of tablets (5 mg) for 1 - 2 pills three times a day. Supporting dose-one tablet three times a day. Applied long. Improvement is usually 1 to 2 weeks; Treatment of about 2 months or more.

     Intravenous (just drip) apply nevrologichesnoy practice in acute ischaemic violations focal cerebral circulation, in the absence of haemorrhage. Enter first 10-20 mg (1 - 2 capsules) 500-1000 ml isotonic sodium chloride solution (drip cefuroxim). If necessary, re-nominate (3 times a day), the slow drip Infusion, then move on to receive the drug inside.

     While the application kavintona to prevent convulsant syndrome in children who have brain injuries. The drug is injected drip rate of 8 to 10 mg / kg / day, 5% glucose solution with the transition after 2 - 3 weeks to go inside to 0.5 to 1 mg / kg per day.

     Reverse usually well tolerated. When intravenously possible hypotension, tachycardia.

     Contraindications : severe ischemic heart disease, heavy adults; Do not use in pregnancy. Do not assign product with labile AD and low vascular tone.

     Injecting drug use is incompatible with heparin solution. We can not impose solutions under the skin.

     Method of issuance : pills to 0,005 grams (5 mg) in a package of 50 pieces; 0.5% solution in ampoules of 2 ml (10 mg).

     Storage : List B. In the dark spot.

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