TSERULOPLAZMIN (Ceruloplasminum).

     Glikoproteid a-globulinovoy factions human blood serum.

     Issued for medical use in a dried powder or amorphous mass blue (blue color is due to the content of copper ions glikoproteide.) . Soluble in water, forms a blue slaboopalestsiruyuschy solution. Gigroskopichen.

     Ceruloplasmin is a blood plasma protein, the body performs a number of important biological functions; Increasing the stability of cell membranes, participates in the immunological reaction, ion exchange, has antioxidant effects, inhibits lipid peroxidation oxidation stimulates disorders. Contents tseruloplazmina in serum significantly reduced when gepatotserebralnoy degeneration (Wilson disease-Konovalov), which is an important diagnostic indicator.

     A drug used for stimulation gemopoeza, reducing intoxication and immunological correction in the integrated treatment of oncological patients; During pre training for the weakened patients with anemia, malnutrition, intoxication; Early posleoporatsionnom period when massive krovopoteri during surgery; When structures septic complications early posleoperahimioterapii cancer patients, including patients with hemodblastoses with nerezko expressed intoxication.

     Ceruloplasmin used in the integrated treatment of patients acute and chronic osteomielitom.

     Enter intravenously (30 drops per minute). The contents of one vial or ampoule dissolve in 200 ml of 5% glucose solution and isotonic sodium chloride solution.

     Cancer patients in the pre training Ceruloplasmin give one dose, 5, 2, 0 mg / kg; Treatment 7 - 10 injections (daily or every other day, depending on the patient).

     In the postoperative period single dose values determined krovopoteri and ranges from 1, 5 mg / kg (with a small loss of blood) to 6 mg / kg (with a krovopotere); Treatment consists of a daily (1 per day) infusion during July - 10 days.

     In himioluchevogo treatment, single dose at 4 to 6 mg / kg, treatment consists of 10 - 14 injections (for a 3 per week). For patients hemodblastoses single dose of 1, 5, 3, 0 mg / kg treated 7 - 10 injection appointed day 1 every day.

     In severe osteomielite single dose of 2, 5 mg / kg, treatment consists of five injections appointed day or every other day. In chronic osteomielite Ceruloplasmin impose on 5 mg / kg of 2 - 3 times at intervals of 1 to 2 days and then make 3 - 7 injection of 2, 5 mg / kg every other day.

     Early treatment can be tseruloplazminom feeling tide of blood to the face, nausea, vomiting, short-term increase in body temperature; Skin plasma (Urticaria). In these cases, lower dose, reduce speed or repeal of the drug.

     Application tseruloplazmina counter to the high degree of sensitivity to drugs protein origin.

     Form release: in vials or ampoule of 0.1 g in the package of five vials or 10 vials.

     Storage: at a temperature of +  5'C.

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