HINGAMIN (Chingaminum). 4 - (1-Metil-4- dietilaminobutilamino) -7 - hlorhinolina hydrates.

     Synonyms: Delagil, Rezohin, Hlorohin, Aralen, Arechin, Artrichin, Atrochin, Avlochlor, Bemephate, Chlorochin, Chloroquine diphosphate, Chloroquini diphosphas, Delagil, Gontochin, Imagon, Iroquine, Klonokin, Malarex, Nivachine, Nivaquine, Quinachlor, Resochin, Roquine, Sanoquin, Tanakan, Tresochin, Trochin and others.

     White or white with a light kremovatym white crystalline powder, bitter taste. Easy soluble in water, very little of alcohol. Aqueous solutions (pH 3, 5, 4, 5) to sterilize + 115 C for 30 min.

     Hingamin quickly cause death asexually eritrotsitarnyh plazmodiev of all types. There are also gamontotsidno. The product is well absorbed and rapidly and slowly available from the body.

     Apply for treatment of acute manifestations of all types of malaria and chemoprophylaxis.

     The range of hingamina not limited impact on malaria plasmodia. He has a delaying effect on the synthesis of nucleic acids, the activity of some enzymes, immunological processes. The product is widely applied in treating kollagenozov (diffuse connective tissue disease): systemic lupus red, sclerodermia and especially rheumatoid arthritis, where he is considered one of the basic products.

     The product has antiaritmicheskoy activity; In patients with arrhythmia and paroxysmal form mertsatelnoy arrhythmia helps restore sinusovogo rhythm. The nature of the actions I antiaritmikam group.

     When treating malaria appoint hingamin inside (after eating) adults and 2, 0-2, 5 g per treatment. At first reception given 1 g (4 tablets of 0.25 g), 6 through 8-h - 0.5 g, in the 2 nd and third days of 0,5 g-1 admission. More designate 0.5 g hingamina in 1-day treatment, mostly in tropical malaria. In tropical malaria treatment may last 5 days; 4 th and 5 th days to give 0.5 g in one reception.

     Higher doses of adult admission inside: single 0.5 g daily 1, 5 g (At first reception usually appoint hingamin in dose exceeding the highest single provided Farmakopeey State).

     Children, depending on age drug designate in the following doses:

     Day dose, the treatment g up to 1 year ,1 year 6, 7 - 10 years, 11 years, 15 years

  1 st 0.05 0.125 0.25 0.5

  2 nd and the third 0,025 0.05 0,125 0.25

     Typically, drug taking inside, but during malignant malaria treatments are starting to vnutrimyshechnogo introduction. Single dose for an adult 10 ml of 5% solution; If necessary, repeat injections spaced 6 to 8 hours, but no more than 3 times (not exceeding 30 ml).

     Intravenous imposed only in especially difficult circumstances: 10 ml of 5% solution razvodyat 10-20 ml of 40% glucose solution or isotonic sodium chloride solution. Enter in the vein slowly.

     After improving patient injections stop and go inside to pick up drugs.

     Children do intramuscular injections only when absolutely necessary; The daily dose should not exceed 8, 3 mg (5 mg of the drug) for 1 kg of body weight; Introducing 2 reception at intervals of a few hours.

     To prevent appoint hingamin inside adults to 0.25 g 2 times a week during the malaria transmission season; Children under the age of doses, which designate the drug in the 2 nd and third days of treatments (see table) .

     When treating rheumatoid arthritis are at 0.25 g (1 tablet) 1 every day after dinner, for 2 to 3 hours to sleep. Treatment long. Curative effects comes after 3 to 6 weeks, sometimes 3-6 months reception drugs: the pain is gradually abating, reducing constraints, improving joint mobility, reduced ekssudativnye phenomenon. Along with the improvement of the clinical picture, SOE declining trend to normalization of blood protein, decreasing the content of C-reactive protein and other effects more pronounced in the case of light and medium gravity-dominated ekssudativnyh events and to a lesser extent, in severe cases, with the prevalence proliferativnyh phenomena. To expedite and strengthen the therapeutic benefits to combine with hingamin glyukokortikosteroidami, non-steroid anti-drugs.

     I think that the therapeutic action hingamina with rheumatoid arthritis is immune effect, preferentially influence on the metabolism of immune cells and connective tissue metabolism. Compared to other basic products (D-Penicillamine, gold and drugs etc.) hingamin considered less effective.

     There are also performance hingamina with disease Bekhtereva (Ankylosing spondylarthritis) Borovskogo disease, and glomerulonefrite amiloidoze kidney, red flat stripping.

     When red lupus, hingamin more efficient with subacute during dominated Clinic joint syndrome. In severe systemic red during yesterday product generally less effective; In these cases should be carefully applied hingamin combined with hormonal therapy in stihaniya acute manifestations of the disease.

     In subacute during red yesterday, hingamin appointed in the first 10 days of 0.25 g 2 times a day (after lunch and dinner), then 0.25 g 1 per day (after dinner); A total of 70 are treated 100 tablets (17, 5, 25, 0 g). In acute stroke during systemic red hingamin combination with hormonal drugs: the first 2 to 3 days hingamin take to 0.25 grams per night, and in the future (with good portability) to 0.5 g (2 pills) per day. Of course 100-120 tablets (25 to 30 grams). In the spring, to reduce the phenomenon fotosensibilizatsii, hingamin can appoint pure; First-1 tablet (0.25 g) 1 every day, then Z-2 tablets per week.

     Separate data on treatment injections vnutrikozhnymi 5% solution hingamina (delagila) diskoidnoy red yesterday, keloidnyh scars, psoriasis; Solution impose intracutaneously (obkalyvanie) 1 - 3 ml 1 3 4 times a day, with blood and keloidnyh scarring and 1 in every 5 - 7 days in the red erythematosus; course 4-20 injection. Courses (2 - 3) with the same 1 - 2-month break. When the pain add 0.2 - 0.3 mL of 2% solution of Novocaine.

     Local treatment hingaminom (delagilom) in the form of electrophoresis in the joints, used in patients rheumatoid arthritis: 5% solution (5 ml), distilled water razvodyat and enter with a negative pole, the current density of 0.03 mA at 1 cm 2; The duration of treatment 15 20 min. At treated 15 to 20 sessions of one session a day.

     As antiaritmicheskogo means sometimes appoint hingamin (delagil) inside of 0.25 g 2 - 3 times a day, gradually reducing the dose to 0.25 g-1 every day. Vnutrivenio to impose kupirovaniya arrhythmia dose of 0.5 grams (with the re-introduction of 0,25 g).

     Short-term use hingamina inside therapeutic doses, normally expressed without side effects. In a lengthy admission may cause dermatitis (often in the form of reddish purple papule reminiscent of the red and depriving razgibatelnoy located on the surface of limbs and torso).

     When dermatitis, reduce or abolish dose of the drug. There may be dizziness, headache, nausea and sometimes vomiting, noise in the ring, a violation of accommodation. Typically, these events are themselves.

     There may also decrease appetite, abdominal pain (due to irritation of the stomach mucosa); For some patients, temporary decrease in body mass. Chance of moderate leukopenia, alleviation of view, in the eyes of VDUs, pigment deposition in the cornea.

     Hingamina Large doses can cause liver damage, Dystrophic changes infarction, posedenie hair retinopathy.

     When treating hingaminom should be common blood and urine tests to monitor liver function and periodic eye examinations.

     In appointing hingamina in combination with other drugs (salitsilatami, stimulation, etc.), should consider increasing phenomenon skin lesions cover (dermatitis).

     In a slow parenteral solutions hingamina no complications, and rapid intravenous might collapse.

     Contraindications: heavy heart disease, diffuse lesions kidney function violations liver disease blood-forming organs.

     Method of production: tablets of 0.25 g; Powder; 5% solution of 5 ml ampoule.

     Storage: List B. Powder-well ukuporennoy packaging keeps out of the light; Pills and ampoule in sheltered from the world scene.

     Presotsil (Presocyl) *. Combined pill, containing 0.04 g (40 mg) chloroquine phosphate (delagila), 0.75 mg prednisolone and 0.2 g acetylsalicylic acid.

     Apply with polyarthritis, fever myofasciitis, inflammatory diseases, musculoskeletal problems. Take 1 - 2 - 3 2 pills twice a day.

     Possible side effects and provopokazaniya see Hingamin, Prednizolon, acetylsalicylic acid.

     Form release: tablets in a package of 30 pieces.

     Produced in Hungary.

Materials allowed to copy only with the active hyperlink to the handbook of medicines