HINIDIN (chinidinum) *.

     Alkaloid contained in the crust tree bark. Is pravovraschayuschim isomer quinine.

     In medical practice using quinidine sulfate (S hinidini sulfas).

     Synonyms: Chinidinum sulfuricum, Quinidini Sulfas, Quinidine Sulfat,

     Conchicinum sulfuricum.

     The white crystalline powder. Soluble in water (about 1%). For headlamps makologicheskim properties similar to quinine, but has a stronger vs. voaritmicheskoe effect.

     Quinidine is "neo" antiaritmicheskih drugs

     Group II.

     It reduces the velocity of the sodium and calcium ions across cell membranes; Osteoporosis reduces anxiety, lengthens Refractory period slowed to a pulse beam Gisa. In high doses might weaken Oxytocics myocardial function, upset conductivity, called blockade heart. Effects of quinidine partly due to the braking oxides processes in the heart. Also found that under the influence of quinidine changing exchange acetylcholine in the heart muscle.

     Quinidine has mestnoanesteziruyuschee (membranostabiliziruyuschee) and the effect is greater peripheral vascular. The product is blocking the transfer of excitation radiation in the end of nerve fibers in the heart; Can lead to frequent cuts ventricular heart.

     Quinidine has strong antiaritmicheskoy activity is effective in different aritmy but relatively often causes side effects.

     However, in some cases, lack of effective drug operation antiaritmicheskih other means, and with the right dosing, it is safe.

     Assign quinidine for kupirovaniya attacks and particularly for making Prevention mertsatelnoy arrhythmia recurrence, as well as paroxysmal tachycardia supraven trikulyarnoy, frequent ventricular arrhythmia and tachycardia.

     Accepted quinidine sulfate inside (for the PC minutes before eating) in the form of tablets.

     Maximum antiaritmichesky effect is that in 2 to 3 hours, the ongoing 4 to 6 hours

     Proposed various schemes of quinidine. Previously appointed poet Din, ranging from small dose (0.1 g) several times a day (six times), with a gradual increase in dose to 0.25 - 0.3 g to 6 times a day. However, the study of the pharmacokinetics of quinidine shows that the need to start with relatively high doses to achieve the optimal concentration of the drug in blood (3-6 µ g / ml).

     In Kardiologicheskom RAMS centre following a pattern of treatment aritmy with IBS: for the first intake designate 0.4 g, and then, if not attack kupirovalsya-to 0.2 grams per hour before ending the attack or to a common dose quinidine 1 year Failing side effects first dose the next attack could be increased to 0.6 d.

     With frequent attacks ventricular arrhythmia quinidine appoint 0,4 0,6 g every 2 - 3 hours.

     In all schemes use daily intake (for adults) should not exceed 4 d.

     When using quinidine should closely monitor the condition of the patient, again a visual study. WHO has described the sharp arrythmia, and the increasing emergence of heart failure require lifting drug.

     In overdose quinidine and individual high sensitive Sty might oppression heart of trepetanie predser rise to ventricular tachycardia, and the so-called hinidinovy shock associated with asistoliey and severe violations of rhythm ventricular (To prevent "hinidinovogo shock" to the registration EKG before each receiving the drug when the daily dose is 0.8 to 1 g, and required further increase and the simultaneous appointment of ephedrine to 0.0125 g (12, 5 mg) for every 0.2 g quinidine.) . There could also reduce AD, and came mielotoksicheskoe effect, nausea, vomiting, diarrhoea, diplopia, allergic skin reactions.

     When treating arrhythmia long mertsatelnoy quinidine can understand tromboembolicheskie complications arose, it is recommended that both appoint BPH.

     Contraindications: increased sensitivity to drugs (idiosin kraziya); Full and partial atrioventrikulyarnaya blockade; Pregnancy; At crucial in the history trombotsitopenicheskoy purpury in connection with the previous admission quinidine.

     The relative contraindications: cardiac failure, expressed hypotension (including acute myocardial heart attack). We should not take note of arrhythmia-related cardiac glycosides intoxication.

     Form release: pills for 0.1 and 0.2 g.

     Storage: List B. In sheltered from the world scene.

Materials allowed to copy only with the active hyperlink to the handbook of medicines