HLORBUTIN (Chlorbutinum). 3-[bis - para-b-Hloretil) - aminofenil] oil acid.

     Synonyms: Leykeran, Hlorambutsil, Amboclorin, Chlorambucil, Chloraminophene, Ecloril, Leukeran, Leukoran, Linfolysin.

     White or white with weak or kremovatym rosy tinge crystalline powder. Almost nerastvorim water easily soluble in alcohol.

     Like other drugs group bis - (b-chloroethyl) - amine, hlorbutin is alkiliruyuschim cytotoxic substances; Have negative effects on tissue and krovetvornuyu giperplazirovannye (tumor) tissue. The product affects more selective at pylori tissue than granulotsitarnye elements.

     Assign hlorbutin inside with chronic leukemia (mostly in leykemicheskih forms), and limfo- retikulosarkome, chlamydia, as well as ovarian cancer.

     Apply inside daily in the form of tablets. Daily dose of chronic leukemia ranged from 2 to 10 mg (depending on the leykotsitoza). The course of treatment for 3 to 6 weeks. Total dose for treatment of 200-400 mg.

     As the number of blood cells in the 25 - to 20 x 10 9 / L, the patient is transferred to the supportive therapy, appointing 2 to 6 mg per week of the year and more.

     For patients with chlamydia leyko- and thrombocytopenia start off with a daily dose of 20 mg; By the end of the course reduces the dose to 10 mg. The number of products on the course of 400-500 mg.

     Hlorbutin used as immunosuppressant. Dose 5 - 10 mg per day.

     Just as in the treatment of other bis - (b-chloroethyl) - amines, during treatment hlorbutinom be systematically (at least 2 to 3 times a week) to blood (general) and differential blood count, determining the number of platelets, blood, hemoglobin .

     In the treatment hlorbutinom may arise leukopenia, anemia and thrombocytopenia; If overdose is much leukopenia, progressiruyushaya until pantsitopenii. Reduced blood can last for 10 to 12 days after preparation.

     In a dramatic development radiation stop receiving the drug, and if necessary, blood transfusion or enter leykotsitnuyu and tumor mass; Designate blood stimulants, vitamins. Transfusion of blood (100 ml - 1, 125 times per week) to produce during the course of treatment.

     Those earlier lechivshimsya other cytotoxic drugs or subjected to radiation therapy, hlorbutin appointed no earlier than 1, 5 -2 months after the previous treatment, as expressed in the absence of radiation, thrombocytopenia and anemia. The product is appointed from the small doses.

     The product contraindications with heavy liver and kidney diseases, acute gastrointestinal tract diseases, after other cytotoxic drugs and radiation therapy, and expressed radiation, thrombocytopenia and anemia associated with the development of malignant process.

     Form release: tablets, containing 0,002 and 0,005 grams (2 and 5 mg) hlorbutina.

     Storage: A. In a list ukuporennoy packaging in a cool, sheltered from the world scene.

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