HLOROPIRAMIN (Chloropyramine)

      The chemical name: N-[(4-Hlorfenil) methyl] - N ', N'dimetil-N-2- piridinil-1, 2-etandiamin (and as hydrochloride)

     Description: Derivative etilendiamina.

     Pharmacology: Farmakologicheskoe action-protivoallergicheskoe, antigistaminnoe, holinoliticheskoe, sedative, sleeping, skin.

Blocks gistaminovye H1- receptors and M-holinoretseptory. Weakened spazmogennoe of histamine on bronchial smooth musculature and ulcers, reduces its hypotensive effect and influence on vascular permeability. Warns development and facilitates a type of immediate allergic reactions. Provides protivozudnoe, sedative and sleeping place. Has moderate peripheral holinoliticheskoy and affects activity.

When admission into fully and rapidly absorbed. The concentration in the blood reaches a maximum for 2 h and stored at therapeutic levels for 4-6 hours Evenly distributed in the body, entering through the GEB. Metabolized in the liver, kidney and bowel displays.

     Application: allergic diseases (Urticaria, rhinitis, conjunctivitis, pollinoz, angionevrotichesky swelling, whey disease), drug allergies, skin diseases (Eczema, contact dermatitis, neyrodermit, skin itching, toksikodermiya), the initial stage of bronchial asthma during the light (of a comprehensive therapy ), acute respiratory infections and intestinal infections in children (in conjunction with analgesics means).

     Contraindications: Hypersensitivity, including other derivative etilendiamina, zakrytougolnaya glaucoma, Benign prostate gland with the expressed violations endoscopy, pregnancy, breast-feeding, breast early age (up to 1 month).

     Restrictions apply to: Worsening erozivno- sex diseases ZHKT delay urination.

     Application of pregnancy and breast feeding: Protivopokazano. At the time of treatment should stop breastfeeding.

     Adverse actions: From the nervous system and sensory organs: poor, weak, slow psychomotor reactions, headaches, dizziness, coordinating traffic violation.

For part of the furniture: drought in the mouth, nausea, gastrointestinal disorders; Seldom-gastralgiya.

     Networking: Funds zaschelachivayuschie urine, increase and decrease zakislyayuschie-therapeutic and side effects. Increases risk of convulsing against analeptics. Increases of narcotic analgesics, general and local anaesthetics, rape and sedation, ethanol. Tricyclic antidepressants help of M-holinoliticheskih and negative effects on the central steps. Barbiturates may accelerate the metabolism and reduce the effects. Deprimiruyuschee effect on the central decreases caffeine and fenaminom rise-klofelinom.

     Overdose: Symptoms: adults-slow, depression, a violation of consciousness until coma, may psychomotor agitation, convulsions, rarely, blood, HYPERTHERMIA. The children - midriaz, blood and HYPERTHERMIA, anxiety, agitation, hallucinations, ataxia, atetoz, convulsions, collapse, coma.

Treatment: Washing stomach, the appointment of activated carbon, salt softeners, the maintenance of heart and respiratory system, if necessary protivosudorozhnaya therapy, IVL.

     Dosing and Administration: inside during the meal, in / m and / in. Adults: 25 mg 3-4 times a day (up to 150 mg / day); The / m in / in-1-2 ml 2% solution. Children: 2-3 times a day for 1-12 months 6.25 mg, 1-6 years, 8.33 mg, 7-14 years 12.5 mg.

     Precautions: In acute allergic reactions and anafilakticheskih treatment beginning with the / in the introduction, then move on to read: In applying the children needed strict medical control (possibly a manifestation of heightened sensitivity). In the early period of treatment prohibited driving vehicles and engaging in activities requiring quick mental and motor responses. There should be no alcohol during treatment.

Materials allowed to copy only with the active hyperlink to the handbook of medicines