HLOZEPID (Chlozepidum). 7-Hlor-2- metilamino-5- ZN phenyl-1, 4-benzodiazepina-4- oxide.

     Synonyms: Napoton, Hlordiazepoksid, Elenium, Ansiacal, Benzodiapin, Chlordiazepoxidum, Chlordiazepoxide, Decadil, Droxol, Elenium, Equinbral, Labiton, Librium, Lixin, Napoton, Novosed, Radepur, Sonimen, Timosin, Viansin and others.

     White or light yellow melkokristallichesky powder. Almost nerastvorim in water, soluble in alcohol difficult.

     Chlordiazepoxide (librium, Chlordiazepoxide) was the first representative of tranquilizers in a group of benzodiazepines. Currently, the group includes a number of more effective drugs, but Chlordiazepoxide their values are not lost.

     Chlordiazepoxide is calming effect on the central causes muscle relaxation, has protivosudorozhnoy activity potentsiruet of rape and analgetikov had moderate widespread effect (usually reflected in continuous use in the first 3 to 5 days).

     Hlozepida characteristic is the ability to suppress a sense of fear, anxiety, stress disorders in the state. Antipsihoticheskogo action is not. In high doses can be reduced psychomotor agitation.

     Farmakokineticheski Chlordiazepoxide (as other tranquilizers this series) is relatively quick vsasyvaemostyu reception inside. Peak concentrations in the blood plasma by a 2 - 4 h; Polususchestvovaniya period 8-10 hours Provided mainly kidneys. Penetrates through the placenta barrier.

     Chlordiazepoxide apply for a position disorders involving anxiety, initiation, tensions heightened irritability, insomnia. It may apply to organ neuroses (functional neuroses cardiovascular system, gastrointestinal tract), migraine, climacteric disorders, etc.

     In anesteziologicheskoy practices can be used to prepare patients pre and postoperative period.

     With regard to the ability of lower muscle tone also apply to spasticheskih condition of defeats head and spinal cord (including violations of traffic in children), and scoliosis, arthritis, bursits and other diseases characterized by muscle strain.

     Assign also with eczema and other skin diseases, accompanied by itching, irritability.

     In psychiatric practice Chlordiazepoxide sometimes used in the border state of events navyazchivosti, anxiety, fear, emotional tension, as shallow and ipohondricheskih depressive state, including those related to dientsefalnoy pathology, as well as a comprehensive treatment of patients with epilepsy and for the treatment of alcohol abstinence syndrome and addiction.

     Doses hlozepida choose individually: usually assign adults (inside) from the 0,005 - 0,01 g (5 - 10 mg) a day; If necessary, gradually increasing doses of 5 to 10 mg per day to a daily dose of 30 mg-50 (3 - 4 admission). Weak and elderly patients product designate smaller doses, children, depending on age-to 0.0025 - 0.005 g (2, 5, 5 mg) for the reception. Terms of the drug, gradually reducing the dose.

     Chlordiazepoxide generally well tolerated by. You may fall, a slight dizziness, uncertainty walking, skin itching, nausea, Constipation, menstrual irregularities, reduction drive. In some cases, early treatment can be observed agitation.

     The product contraindications with acute liver and kidney disease in infants. It should appoint a monoaminoksidazy inhibitors (see), and derivatives fenotiazina. Do not appoint Chlordiazepoxide (as well as other drugs in this group) during pregnancy. The product should be taken prior to and during transport of drivers and others whose work requires quick mental and physical reactions. During treatment hlozepidom and other drugs in this group must strictly refrain from the use of alcohol.

     Form release: tablets, containing 0,005 grams hlozepida covered with yellow skin, in a package of 50 pieces.

     Storage: List B. In sheltered from the world scene.

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