HOLINA CHLORIDE (Cholini chloridum).

  (2 Oksietil) - trimetilammony chloride.

     Synonyms: Bilineurine, Choline chloride, Cholinium chloratum, Luridine.

     White crystals or a white crystalline powder with a characteristic smell amines. Very gigroskopichen. Very easily soluble in water, easy-to alcohol. Aqueous solutions (pH 20% solution of 5, 5, 7, 0) + sterilize with a temperature of 100 C for 30 min.

     Choline chloride term refers to a set of vitamin B. Is gruply substances from which the body is formed acetylcholine, a key mediators nerve stimulation.

     Choline is a member of the fosfolipida method, which is an important part of the cells. Playing a major role in the exchange fosfolipidov; Involved in the process fosfolipidov synthesis in the liver. Lack of choline in animals leads to the development of fat infiltration and haemorrhagic namely liver and kidney involyutsii zobnoy gland.

     Choline is one of the main representatives of the so-called lipotropnyh substances that prevent or reduce lipid infiltration of the liver. He also serves as an important source metilnyh groups to occur in the body biochemical processes (See also Metionin, Calcium pangamat.) .

     Choline is weak atsetilholinopodobnym actions; Several stimulates bowel muscles. In high doses can cause agitation M-holinoreaktivnyh body's systems.

     A large number of choline found in egg yolk, liver, embryo cereals, cabbage, spinach.

     Need adults choline is 0.5 to 1, 5 g per day.

     As drug use choline chloride obtained by synthetic.

     Assign choline chloride with liver disease: Botkina disease, hepatitis, liver cancer (mainly in the early stages), hypothyroidism, tsistinurii, atherosclerosis, chronic alcoholism.

     Inside are in a 20% solution of 1 tea spoon (5 ml) 3 - 5 times per day (3 to 5 g choline chloride per day).

     In the vein type drip method in a 1% solution of isotonic sodium chloride solution, or 5% glucose solution at speeds of no more than 30 drops per minute. In a reception to introduce 200 - 300 ml (2 to 3 g).

     Intravenous a supplement supplies 20% solution of the drug inside.

     The length of treatment depends on the condition of the patient, ranging from 7 to 10 days before the W-4 weeks or more to the total number of drug treatment for one 80-100 mg.

     When you receive inside diarrhoeic rarely observed phenomenon. With rapid intravenous introduction may be feeling heat, nausea and sometimes vomiting, aetiology, lowering blood pressure, even collapse. These phenomena are related to the initiation of peripheral holinoreaktivnyh body's systems. To avoid their choline chloride solutions should be imposed only in the veins drip method in the hospital.

     Method of issuance: powder; 20% solution in 10 ml ampoule; For drip infusion prepare 1% solution.

     Storage (powder): a well ukuporennoy packaging.

     R p. Sol. In holini with hloridi 20% 100 ml

     D.S. At one tea spoon three times a day

     R p. : Sol. In holini chloridi 20% 10 ml

     D.t.d. N. in ampull 10.

     S. For intravenous drip infusion (preliminary but razvesti in 5% glucose solution for a 1% solution)

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