KLOMIFEN (Clomifene)

     Chemical name : 2-[4 - (2-Chloro-1, 2-difeniletenil) phenoxy] - N, N-dietiletanamin (in the form of citrate)

     Description : Black or white with a white crystalline powder Cream. Little is soluble in water, soluble in alcohol moderately.

     Pharmacology : The drugs act-antiestrogennoe.

Links estrogen receptors in the hypothalamus and ovaries. When ingestion well absorbed from the digestive tract. Metabolised in the liver. Excreted in bile, is enterogepaticheskoy recycling. Of the organism appears to feces. T1 / 2 days at 5-7. In low doses enhances the secretion of hormones gonadotropnyh (prolactin, FSG and LG), stimulates ovulation. With low in the body of endogenous estrogen has been moderate oestrogenic effect on high-antiestrogenny. By reducing the level of circulating estrogen contributes gonadotropinov secretions. In high doses inhibits secretion gonadotropinov. Gestagennoy and androgennoy activity is not.

     Application : Anovulyatornoe infertility (ovulation induction), dysfunctional uterine bleeding, amenorrhea (disgonadotropnaya form, secondary, postkontratseptivnaya) Galactorrhea (in the face of pituitary tumors), polycystosis ovaries (syndrome Stein - Leventalya) - Chiari syndrome Frommelya, androgennaya deficiency, oligospermiya, to diagnose violations gonadotropnoy pituitary function.

     Contraindications : Giperchuvstvitelnost, severe hepatic renal failure, uterine bleeding unknown etiology, ovary cyst, tumour or inadequate pituitary function, pregnancy (including suspected it).

     Application of pregnancy and breastfeeding : Protivopokazano pregnancy.

     Side Effects : From the nervous system and sensory organs : headache, dizziness, depression, fatigue, anxiety, insomnia, visual.

For part of the digestive tract : nausea, vomiting.

From the urogenital system : cystic ovarian increase, dismenoreya, pollakiuriya, poliuriya, multiple pregnancy.

Other : tides, increased body mass, lower abdominal pain in the chest, nausea (men), hyperthermia, reversible hair loss, allergic skin reactions.

     Networking : Compatible with drugs gonadotropnyh hormones.

     Overdosing : Symptoms : nausea, vomiting, tides, a disorder, pain in the abdomen.

Treatment : symptomatic therapy.

     Dosing and Administration : inside. To stimulate ovulation appoint one 50 mg once a day at night, from 5-day menstrual cycle within 5 days (in the absence of the cycle at any time); If no effect (ovulation does not occur within 30 days), increased the dose to 100 mg / day or a course lengthened to 10 days. Heading dose should not exceed 750 mg. The advent of ovulation determined by the presence of two-phase basal temperature, the average cyclical increase LG products, increased levels of progesterone during whey likely secondary phase lyuteinizatsii or menstrual bleeding women with amenorrhea. If ovulation has occurred, but no pregnancy occurred, the course should be repeated. If held after ovulation no menstrual bleeding, should take into account a possible pregnancy. Men appoint 50 mg 1-2 times a day for 3-4 months (a systematic monitoring spermatogrammy).

     Precautions : Before and during treatment continued monitoring gynaecologist should check ovarian function, the study of vaginal, watch the phenomenon of "maybe", etc. While the ovaries or treatment of cystic transformation klomifenom suspended until the size of the ovaries. Therapy continued with minimal doses or shorten the treatment period. Against the backdrop of treatment is recommended to monitor liver function. Do not assign work without excluding persons, occupations that require rapid physical and mental reactions.

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