KLOMIPRAMIN (Clomipramine) *. 3 Hlor-5- [3-(dimethylamino) propyl] -10,11-dihydro-5 H-dibenzo [b, f] - azepin.

     Synonyms : Anafranil, Anafranil, Chlorimipramine, Hydiphen, Klomipramin, Maronil, Monochlorimipramine, Neoprex.

     Available as hydrochloride.

     The structure of imipramina distinguished by the chlorine atom in a molecule.

     On pharmacologically also close to imipraminu but is a stronger influence on blocking reverse takeover neyronalny serotonin (see Trazodone, Fluoxetine).

     Has expressed timolepticheskoe a less pronounced than imipramina, enabling component.

     When applied in different forms depressions, including in-depth, long form. The effect is relatively fast (3 - 5-day).

     Assign usually 0,025 g (25 mg) three times a day, if necessary, increasing the dose to 50 mg, and more than 3 times a day. In severe depression set in the vein (slowly!) 25-50 mg to 200 mg. Upon reaching the therapeutic effect moving to a reception drug inside.

     Adverse events and contraindications essentially the same as for imipramina. Unlike imipramina clomipramine not usually heightens fear and anxiety.

     Method of issuance : capsules and tablets of 10; 25 and 50 mg, 1% solution in 25 ampoules of 2 ml (25 mg in the ampoule).

     Storage : List B.

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