KOKARBOKSILAZA (Cocarboxylasum).

     Difosforny broadcast thiamine. Tiamindifosfat.

     Synonyms : Kotiamin, Tiaminpirofosfat, Berolase, Bioxilasi, B-Neuran, Cobilasi, Cocarbil, Cocarbosyl, Cocarboxylase, Coenzyme B Cothiamine, Diphosphothiamin, Pyruvodehydrase and others.

     Kokarboksilaza close on the biological effects of vitamins and enzymes. Is prosteticheskoy Party (kofermentom) [see Enzymatic preparations] enzymes involved in the Carbohydrate exchange. In connection with protein and magnesium ions is part of the enzyme karboksilazy, catalytic karboksilirovanie and decarboxylation a-ketokislot.

     Thiamin (vitamin B 1), introduced in the body to participate in the above biochemical processes must first fosforilirovatsya and become kokarboksilazu. Last thus is finished form kofermenta, formed from thiamine in the process of making it in the body.

     For medical use kokarboksilaza appears as kokarboksilazy hydrochloride (0.05 g) for injection (P ocarboxylasi hydrochlridum pro injectionibus 0.05).

     It is a porous mass freeze dry white with low specific smell. Gigroskopichen. The easily soluble in water (pH 2, 5% solution of 1, 2, 1, 9). Solutions are filled immediately before use.

     The biological properties kokarboksilazy not coincide with the properties of thiamine, and for the treatment of beriberi and weight in one kokarboksilazu not apply. Testimony to serve its intended purpose : diabetic origin disorders, liver and kidney failure, respiratory disorders in chronic pulmonary heart syndrome, liver and diabetic coma, circulatory insufficiency coronary and peripheral neuritis, various pathological processes that require improvement Carbohydrate exchange. 0 kokarboksilaza rarely used as a component of combination therapy.

     Enter kokarboksilazu intramuscularly, sometimes under the skin or intravenously. Dose Adult 0.05-0.1 1 g once a day for children - 0,025 - 0.05 g 1 per day. The course of treatment 15 to 30 days.

     In diabetes (acidosis, coma) daily intake is estimated to be 0.1 to 1, 0 g (without interrupting normal protivodiabeticheskoy therapy).

     Product : with a capacity of 3 ml ampoules containing 0.05 g product in a package of 5 or 10 vials complete with a 5 or 10 mg solvent.

     Storage : in the dark place at a temperature of no higher than 5 'Ñ.

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