KORTIZON (Cortisonum)

     For use in medical practice produce eye acetate (Cortisoni acetas).

     Pregnen-4- diol - 17, a 21-Triona-3, 11, 20,21-acetate.

     Synonyms : Adreson, Cortadren, Cortelan, Cortisate, Cortisone acetate, Cortistab, Cortistal, Cortisyl, Cortogen, Cortone, Incorten, Rincorten and others.

     White or white with a yellowish sheen weak crystalline powder. Almost nerastvorim in water, very little is soluble in alcohol.

     Assign inside or intramuscularly (a suspension), with testimony to the application of glucocorticosteroids.

     Inside are usually in the early days of treatment for 0.1 - 0.2 g / day (3 - 4 admission), then gradually reduce the dose to the minimum, sufficient to maintain the therapeutic effect (average 0,025 g / day). Heading dose of rheumatism is 3 - 4 years

     Intramuscularly imposed on the 0,025 - 0.05 g 1 times a day or two times with intervals from 8 to 12 h.

     The operation after a single reception inside continues 6 to 8 h after intramuscular introduction (in the form of suspension), 8 - 12 pm

     When illness Edison cortizone nominated jointly with dezoksikortikosteronom while introducing sodium chloride. Usually take on 0.0125 - 0.025 g / day (12, 5, 25, 0 mg) eye, 0,001 - 0,005 grams (1 to 5 mg) dezoksikortikosterona acetate and 4-6-10 g sodium chloride . It is also recommended that the combination of eye with ascorbic acid.

     Higher doses of eye acetate for adults : single 0.15 grams daily 0.3 g.

     Children cortizone designate smaller doses; It should be borne in mind that the number of drug must match the severity of the illness rather than age. Young children usually on the 0,025 - 0.0125 g 3 times a day for 2 days, then 2 times a day, then reduce the dose to maintenance; School-age children - to 0,025 g three times a day, then two times a day, then reduce the dose to the minimum, sufficient to maintain the therapeutic effect. Is inside or impose intramuscularly.

     Cortisone, like other steroidiye hormones should be used under medical supervision. Patients must carefully examine in the future systematically monitor blood picture, weight, blood pressure, blood glucose content and the psyche.

     Cortisone often than other drugs glyukokortikosteroidnye is side effects. Leaving treatment and high doses (more than 0.1 grams per day) may appear virilnoe obesity, girsutizm, acne, menstrual irregularities, osteoporosis, syndromic Itsenko - Kushinga, personality disorders and other possible pitting digestive tract, puncture unrecognized canker hemorrhagic pancreatitis.

     The emergence of a more efficient, better carry synthetic drugs glyukokortikoidnyh cortizone is currently limited.

     Precautions and contraindications to the use of the same as for all glucocorticosteroids.

     Method of issuance : pills to 0,025 and 0.05 g; Suspension in vials containing 10 ml (1 ml suspension contained 0,025 grams eye acetate).

     Storage : List B. In the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines