KRIZANOL (Crysanolum).

     A mixture containing 70% aurotiopropanolsulfonata calcium and 30% calcium gluconate. Contains 33, 5% gold.

     For medical use of the form of 5% of oil mist injection (P risanolum oleosa 5% of injectionibus p r). 1 ml mist contains about 17 mg of gold.

     A similar product produced abroad under the name "0leochrysin e".

     Krizanol is one of the main gold-drugs used as a base for the treatment of rheumatoid arthritis (see also Penitsillamin, Non-steroidal anti-inflammatory drug).

     Mehnnizm of gold drugs is not clear. I believe, however, that their therapeutic effect is partly due to the influence of the immune processes : they inhibit the humoral immunity, while also stimulating the cellular immune response, and therefore they can be attributed to ummunomodulating drugs.

     Earlier, before the advent of modern antibiotics and synthetic anti chemotherapy drugs krizanol relatively widely used in the treatment of pulmonary tuberculosis fresh and larynx.

     Applied krizanol intramuscularly. Before use, suspended in the ampoule and have vzbaltyvayut. Dose individualiziruyut depending on the course of the disease and endurance drug. Usually imposed from 2 ml of 5% mist; Producing 10 injections at intervals 2 - 5 days. Then enter to 4 ml 5% mist and also made 10 injections with the same intervals. Total 20-25 injection. However, a more precise dosing, can improve efficiency and reduce side-effects, is in control of the concentration of gold in plasma.

     When treating rheumatoid arthritis should enter drug doses not exceeding 34 mg of gold per week; The minimum weekly dose of 17 mg of gold (1 ml of 5% mist). The best is the concentration of gold in the 250-300 serum mkg/100 ml. Treatment should be long-term (1, 5, 2 years).

     While krizanolom can appoint steroidal anti-inflammatory drug (see).

     There are performance krizanola psoriaticheskogo in treating arthritis.

     In applying krizanola, especially in cases of overdose possible side effects : Nephropathy, dermatitis, stomatitis, anaemia. When dermatitis, diarrhea, pathological changes in the pattern of blood protein and blood in the urine, it is necessary to increase the intervals between the injections or stop further use of the drug.

     Krizanol contraindications to kidney disease, diabetes, heart urological defects, cachexia, miliarnom tuberculosis, fibrozno- kavernoznyh processes in the lung, blood irregularities, pregnancy. It should not be used in conjunction with krizanolom immune drugs.

     Product : 5% of oil suspended in 2 ml ampoules in a package of 25 vials.

     Storage : List B. In the dark spot.

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