TSITARABIN (Cytarabinum). 4-Amino-1 -b-D- arabinofuranozil-2 (1 H) - pirimidinon or 1-b-D- arabino- furanoziltsitozin.

     Synonyms: Alexan, Tsitozar, Alexan, Aracytidine, Cytarabine, Cytosar, Cytosinarabinosid.

     The white crystalline powder. According to the structure and operation of the antimetabolitam - pirimidina analogues.

     Apply with acute leukemia (mostly nelimfoblastnyh forms) and blastnyh mieloleykozov chronic crises.

     Enter tsitarabin intravenously (kapelno or infuzionno) subcutaneously and intratekalno.

     The product can be used alone and in combination with other cytotoxic means (tsiklofosfan, vinkristin, tioguanin, L-asparaginase, rubomitsin, karminomitsin) and prednisolone. The effectiveness of the drug is subject to dynamic changes of blastnyh cells in peripheral blood and bone brain.

     Daily tsitarabina dose is 100 mg / m 2 1 surface of the body, exchange dose in all ways of 500-1000 mg. For patients older or with reduced blood reserves using smaller doses of the drug-50-75 mg / m 2.

     Just before using the contents of the vial dissolve isotonic sodium chloride solution or sterile water for injection (intravenous 400 ml; For subcutaneous and intratekalnogo in 1 ml).

     Intravenous daily dose (100 mg / m 2) tsitarabina introducing two transfuzy drip slowly (3 h) within 10 hours

     With limited daily dose of the drug to enter in 24 hours

     Subcutaneously tsitarabin apply to 20 mg / m 2 2 - 3 times a day.

     Assign each day during the 4 to 7 days or more (up to 10 days). Just a 4 - 7 courses at intervals of 10 to 14 days and more.

     Intratekalno to prevent neyroleykozov, product type 1 every 3 days for 15 days in a single dose of 20 mg / m 2 (usually in combination with metotreksatom in 12 dose, 5 mg / m 2). To determine individual portability preparation in these cases may gradually increase occasional dose of 3 to 20 mg / m 2. Just a 4 - 7 courses. Intervals between rates of 10 to 14 days and more.

     In applying tsitarabina possible leukopenia, thrombocytopenia, anemia, megaloblastoz, nausea, vomiting, loss of appetite, pain in the abdomen, diarrhea, inflammation and pitting oral mucosa, trombophlebitis breach of liver function, rarely violation kidney function (in this case should be reduced the drug dose or stop).

     Treatment should be under the control of tuberculosis (daily or every other day) and blood as bone marrow (before and after each course of therapy). A control function of liver and kidneys.

     The product contraindications for heavy violations of the liver and kidneys, with beremennostn.

     Form release: dried powder or porous mass in vials of 0.1 g in the package of 10 vials.

     Storage: List B. If temperature does not exceed  +5 C.

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