DAKTINOMITSIN (Dactinomycinum).

     Antibiotics aktinomitsinov group of products Str. parvullis and other aktinomitsetov.

     By building a akrinotsinil- di - (L-treonil-D- valinil-L- prolinilsarkozil-N- metil-L- valinil) - laktonom.

     Synonyms : Aktinomitsin D Actinomycin D, Cosmegen, Cosmogen, Meractinomycin.

     Powder orange red. It is soluble in water at a temperature of + 8 C to + 10 C, almost nerastvorim in water at a temperature of  +37 C.

     The drug has antitumor activity. The basis of the mechanism of action is the education of the antibiotic with DNA and in violation of its Matrix activity.

     Applied alone or (more likely), in combination with other drugs and radiation therapy, with USSR disease (horiokartsinoma uterus), tumors Vilmsa, retikulosarkome, rabdomiosarkome (children), Ewing tumors, malignant tumors testis, chlamydia and other tumors. The drug is also used in combination chemotherapy disseminated melanoma.

     Enter intravenously as a ready solution for injection (Solutio Dactinomycini pro injectionibus) - transparent liquid orange; PH 4, 0, 6, 5. In 1 ml containing 0.5 mg (500 ug) daktinomitsina.

     Implement 5-7-day course to repeat courses through 3 - 8 weeks. Under the dose for adults 10 µ g / kg for children 15 µ g / kg (in the calculation of body surface area of 450 µ g / m 2 for adults and children). Using 20-day treatment with a single dose of 5 µ g / kg every other day. When bad Portability reduce or increase the dose interval introduction.

     Actinomycin can be used in combination with other chemotherapy drugs (adriamitsin, tsiklofosfan, etc.) and radiation therapy.

     In applying the drug may nausea, vomiting, increased body temperature, stomatitis, skin deterioration, alopeniya. The relatively frequent radiation, thrombocytopenia, pantsitopeniya.

     Treatment must be carried out under the close supervision of a doctor; The content in the blood leukocyte determine daily platelets-at least 1 in every 3 days. When the cells below 4 x 10 9 / L and platelets less than 150 x 10 9 / L introduction of a drug stop. We also need to monitor the functions of the liver and kidneys.

     The solution may not be getting under the skin because of the possible development of necrosis.

     The drug is not suitable for heavy general patients with leukocyte number less than 4 x 10 9 / L and platelets less than 150 x 10 9 / L, with the pregnancy, a violation of the liver and kidneys.

     Product : injection (Solutio Dactinomycini pro injectionibus) and 1 ml (in reopoliglyukine) containing 0.5 mg drug.

     Storage : List A. In the dark place at a temperature no higher than  +10 C.

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