DALTEPARIN sodium (sodium Dalteparin).

     Synonym : Fragmin, Fragmin.

     Diluted nizkomolekulyarnogo incidents with molecular weight of about 5000 Dalton.

     Contact with antitrombinom III accelerates its interaction with trombinom; Moreover, blocks activated factor X (a shift in trombina metatrombin inactive).

     Closure blood slowing slightly. Suppress aggregation, but not adhesion of platelets.

     Has anti-and immunosuppressing.

     Indications are the same as those nadroparina calcium.

     According to published data overseas, in patients with unstable angina and heart attacks without super Q dalteparin sodium by brief application (6 days) exceeded atsetilsalitsilovuyu acid (but not nefraktsionirovanny heparin) for a reduction in the frequency of repetitive heart attacks and other complications.

     Enter subcutaneously or intravenously (intramuscular a banned!) .

     To prevent deep vein thrombosis and pulmonary embolism in surgery impose subcutaneously : with a moderate risk for 2500 IU for 1-2 h before the operation, then one every day for 5-7 days or more; At high risk for 2500 IU every 8-12 hours, then 5000 IU 1 time per day for 5-7 days or more.

     When treatment also increased deep vein thrombosis and pulmonary embolism are subcutaneously, depending on the weight of 10,000 -18,000 IU (200 IU / kg) 1 every day (with increased risk of bleeding 100 IU / kg 2 times daily) in during at least five days of moving to the proximity anticoagulants.

     In unstable angina and heart attacks without super Q impose subcutaneously to 120 IU / kg (up to 10,000 IU), 2 times a day for 5-8 days.

     Possible side effects and contraindications are the same as those nadroparina calcium.

     Product : injection of disposable syringes to 0.2 mL (2500 and 5000 IU), and 1 ml ampoules (IU) (10000 N. 10).

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