Dezoksikortikosterona trimetilatsetat (desoxycorticosteroni trimethylacetas)
DEZOKSIKORTIKOSTERONA TRIMETILATSETAT (Desoxycorticosteroni trimethylacetas).
Pregnen-4- ol-21- glows - 3, 20-trimethylsilyl acetate.
Synonyms : Desoxycorticosteronum trimethyl-aceticum, Percorten M.
The white crystalline powder, nerastvorim almost in the water, little is soluble in alcohol.
By building and the biological effects dezoksikortikosterona trimethylsilyl acetate close to dezoksikortikosterona acetate (DOKSA). The chemically different from the past so that the hydrogen atoms of methyl groups in regulation 21, replaced by three methyl groups. In addition, the intramuscular introduction of an appropriate suspension gives lasting impact. Like DOKSA, dezoksikortikosterona trimetilatsetat is a synthetic analogue of adrenal cortex hormone-dezoksikortikosterona; Mineralokortikosteroidov belongs to the group.
Indications for use dezoksikortikosterona trimetilatsetata the same as DOKSA : Edison disease, the relative lack of adrenal cortex, hypotensive syndrome, asthenic conditions with hypertension caused by infectious diseases, dientsefalno- hypophyseal insufficiency, etc. If necessary, apply dezoksikortikosterona trimetilatsetat in combination with glyukokortikosteroidami.
Enter drug intramuscularly in the form of water 2, 5% and 1 ml suspension. Injections make one every two weeks. Treatment must be carried out under the supervision of a doctor. Overdosing can cause swelling (due to the delay of sodium and water), increase blood pressure. In these cases, the dose should be reduced and to limit the use of sodium chloride and liquid. To avoid development gipokaliemii patients should meal, rich in potassium (fruits, vegetables). Doing gipokaliemii designate potassium salt (chloride or ammonium acetate) by 0.5 to 1, 0 g 2 - 3 times a day.
Contraindications to the use dezoksikortikosterona trimetilatsetata are hypertension, heart failure with stagnant, kidney disease violation function of liver cancer.
Product : 2, 5% for injectable suspension in 1 ml (25 mg product).
Ampoules of a carefully vzbaltyvayut to education ravnomer by mist.
Storage : List B. In cool, the dark spot.
Rp. : Susp. Desoxycorticosteroni trimethylacetatis 2, 1 ml 5%
D.t.d. N. in ampull 6.
S. On January 1 ml intramuscularly once every 2 weeks
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