DEZOKSIRIBONUKLEAZA (Desoxyribonucleasum).

     Dezoksiribonukleaza enzyme is contained in the pancreas and intestinal mucosal lining; Protein albuminovogo type. Hydrolyzation (depolimerizuet) DNA dezoksiribonukleotidov education.

     For medical applications from the pancreas of cattle. Represents dried white powder soluble in water and isotonic sodium chloride solution; PH 0.1% aqueous 3, 0, 5, 5. Aqueous solutions (and powder) inaktiviruyutsya when heated above 55 'S.

     Activity determine Education kislotorastvorimyh products released product in certain circumstances of DNA; It is expressed in units of action (EA). At 1 mg product should contain not less than 1700 EA.

     Drugs close to the action dezoksiribonukleaze, produced abroad under the title "Ra n with r ea tic dornase, Dornavac and others.

     Dezoksiribonukleaza has the ability to hamper the development of herpes viruses, Adenoviruses and other viruses containing DNA. The effect associated with depolymerization DNA oligonucleotides to the mono-and by splitting mezhnukleotidnyh ties. By stifling the synthesis of viral DNA damage dezoksiribonukleaza not yet macro-cell DNA.

     Dezoksiribonukleaza is also depolymerization and liquefaction cancer.

     When applied faster and keratouveitah keratitis, conjunctivitis and keratitis Bixby, abscesses lungs, severe pneumonia virus upper respiratory tract adenovirusnoy nature; To reduce viscosity and improve evacuation sputum and get in Bronchoectatic disease, abscesses lung atelectasis, pneumonia; In pre - and aftercare of the times patients with introducing diseases, tuberculosis light.

     For exterior use dezoksiribonukleazu a 0.2% solution (2 mg preparation of 1 ml) of isotonic sodium chloride solution. Solutions are daily; Expiration date of the solution, 12 hours

     In keratouveitah herpetic keratitis and impose affected by conjunctival eye daily on 0.5 ml of sterile solution dezoksiribonukleazy within 2 to 4 weeks. In addition, the fluid in the eye of 2 to 3 drops of 0.2% solution of 3 - 4 times a day. To prevent recurrence continue to impose medication for 6 to 10 days after resistant clinical improvement.

     To treat Bixby keratokonyunktivitov give konyunktivalnuyu cavity for 1 to 2 drops of 0.05% solution of distilled water every 1 5-2 hour during the day.

     When acute bronchitis virus upper respiratory tract adenovirusnoy Nature solution buried in the nose or give an aerosol; Inhalation of 10 to 15 minutes 2 to 3 times a day for 2 to 5 days. At each inhalation - 3 ml of 0.2% solution.

     If nagnoitelnyh processes in the lungs, enter solution inhaled in aerosol form at a rate of 1 ml for 10 - 15 minutes. At each inhalation spend about 3 ml. Inhalation produce 3 times a day for 7 to 8 days.

     There is a positive effect dezoksiribonukleazy with acute viral hepatitis, gerpetiformnoy Kaposi eczema, and other diseases. In these cases, parenteral drug use. The question of the application of parenteral drug needs further study.

     When local application dezoksiribonukleazy may, in some cases, allergic reactions. For patients with bronchial asthma may experience some increase in attacks, which require interruption of treatment or eliminating drug. In case of hypersensitivity drug overturned.

     Product : in the hermetically ukuporennyh bottles; Containing 5; 10; 25 and 50 mg.

     Storage : dry, the dark place at a temperature of not more than 20 'C.

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