DEKSAMETAZON (Dexamethasonum). 9 Fluorine-11-b, 17, a 21-trioksi a 16-pregna-methyl-1, 4-diene 3, 20-dione, or a 9-fluorine-16 - a metilprednizolon.

     Synonyms : Amradexone, Arcodexan, Cortadex, Deason, Decacort, Decacortin, Decadin, Decardan, Decardon, Decasterolone, Dekacort, Desometon, Dexacort, Dexamecortin, Dexametan, Dexason, Dexone, Hexadecadrol, Hexadrol, Millicorten, Minicort, Novomethasone, Oradexon, Prednisolon F , Resticort, Steralol, Superprendol, Wymesone and others.

     White or white with a yellowish sheen crystalline powder. Almost nerastvorim in water, soluble in alcohol difficult.

     A characteristic of the chemical structure is the existence of dexamethasone in the fluorine atom molecules. As of the body close to other glyukokortikosteroidam, but more active, and has a strong anti antiallergic effect.

     On the effectiveness of 0.5 mg dexamethasone approximately 3, 5 mg prednisolone, 15 mg hydrocortisone or 17, 5 mg eye; Thus, it is seven times more prednisolone and 35 times more eye.

     Indications for use mainly the same as for other similar drugs : rheumatoid arthritis, Medicine, argued syndrome, allergic diseases (bronchial asthma, etc.), chlamydia and others.

     Assign inside. Normal daily intake for adults is 0,002 - 0,003 grams (2 to 3 mg); In severe cases, it increased to 0,004 -0,006 g, after the therapeutic effect gradually lower the dose; Supporting dose equal to 0.0005 - 0,001 grams (0.5 to 1 mg) a day. Daily dose appoint 2 - 3 admission during or after eating.

     Children are designated according to the age of 0.00025 grams (0.25 mg = 1 / 2 tablets) to 0,002 grams (2 = 4 mg tablets) a day for 3 to 4 admission.

     Preparation is well tolerated. In therapeutic doses relatively little effect on the exchange of electrolytes and is usually delayed sodium and water in the body. It must, however, keep in mind that in high doses and with sensitivity, and the drug may cause side effects common to other glucocorticosteroids; Treatment must be carried out under close medical observation in the light of possible complications and contraindications.

     Treatment stop gradually, as well as the application of glucocorticosteroids other; At the end of treatment to appoint several kortikotropina injection.

     Product : pills to 0.0005 g (0.5 mg).

     Storage : List B. In dry, the dark spot.

     In severe cases, adrenal insufficiency, shock and unconscious, etc. and injected intramuscularly soluble form of dexamethasone (deksametazon-21- phosphate as sodium salt), produced in 1 ml ampoules containing 0,004 g of the drug (4 mg).

     Deksametazon-21- phosphate sodium salt imposed by 1 to 2 ml per day.

     After a therapeutic effect dexamethasone take inside.

     Retrobulbarno introducing soluble dexamethasone (in ophthalmic practice).

     In psychiatric practice, dexamethasone is used to diagnose disorders disorder (called deksimetazonovy test). With the introduction of dexamethasone results in a reduction of hydrocortisone (cortisol) in the blood. In some types of disorders, including depression, this is not happening.

     Dexamethasone for diagnostic purposes appointed interior adult dose of 1 to 2 mg, 0.5 mg children.

     For use in ophthalmic practice abroad produced eye drops : dexamethasone 0.1% Ophthalmic Suspension (in vials of 10 ml); Oftan- dexamethasone (Oftan- Dexsametason) containing 1 ml of 1 mg (0.1%), dexamethasone-21 - phosphate.

     These drops used in allergic conjunctivitis, keratitis, keratokonyunktivitah, iritah, iridotsiklitah, as well as to reduce the inflammatory events after eye operations injuries.

     Buried on 1 - 2 drops : early treatment every 1 to 2 hours, and then, with a decrease in inflammatory events every 4 to 6 hours The duration of treatment may vary from 1 to 2 days to a few weeks (depending on the outcome).

     The use of eye drops with dexamethasone contraindicated in viral and fungal diseases of the eye and acute eye infection prophylaxis (unless protivoinfektsionnoy therapy).

     Note that prolonged use of drugs, as well as other eye drops containing corticosteroids may lead to increased inner pressure. In refining the cornea, the skin there is a risk of perforation. When herpes simplex may occur distribution process.

     Storage : List B. In a cool place.

     Glaznye- ear drops <<Deksona>> (<Dexona>) containing 0.1% solution of dexamethasone sodium phosphate and 0.5% solution of neomycin sulfate; Issued in flakonah- looks to 5 ml.

     Applied with conjunctivitis, keratitis, blefaritah, pneumonia and middle ear etc.

     In the eyes buried in 1 to 2 drops of 3 to 4 times a day, ears-3 - 4 drops of 2 - 3 times a day.

     Contraindications : viral diseases and tuberculosis eye, leaving a simple, fungal diseases.

     Storage : Keep in a cool place.

     Issued and other drugs, which include dexamethasone. Deksokort (Dexocort; Poland) - aerosol containing dexamethasone with neomycin. It has antibacterial and antiinflammatory effects in skin diseases.

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