DEKSRAZOKSAN (Dexrazoxane).

     (+)-( S) -1,4 - Propilendi-2, 6-piperazindion.

     Synonym : Kardioksan, Cardioxan.

     The white crystalline powder. Well soluble in water.

     Cycles analogue EDTA (ethylene acid).

     Forms chelate with salts of iron and copper.

     Violate the education of doxorubicin-iron (and other antibiotics antratsiklinovyh with iron), and prevents the appearance of iron-free radicals, oposreduyuschih kardiotoksichnost antratsiklinovyh antibiotic therapy.

     Assign to prevent cardiomyopathy when applying antratsiklinovyh antibiotic therapy.

     Enter intravenous drip adult dose of 0.5 g / m 2 (0.5 g dissolve in the 0,167 M solution of sodium lactate concentrations up to 10 mg / ml or 0.9% solution of sodium chloride or 5% glucose solution to the concentration of 1 3-5 mg / ml) for 30 min before intravenous dose of doxorubicin 50 mg / m 2 or (scheme II) in the dose of 1 g / m 2 (0.5 g dissolved in 25 ml of water for injection, then the solution ringer lactate or sodium lactate to 250-500 ml) for 45-60 minutes prior to the introduction of doxorubicin (first 20-30 minutes cefuroxim, then 20-30 minutes). Let's ex tempore. Best Solution for 6 h after preparation.

     Possible side effects : neuralgia, Alopecia, radiation, thrombocytopenia, pain at the injection.

     The drug is contraindicated in pregnancy and breastfeeding.

     Product : dried powder for injection solutions in bottles of 0.5 g complete with solvent.

     Storage : List B.

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